Cargando…
Evaluation of Microbiome Alterations Following Consumption of BIOHM, a Novel Probiotic
Gastrointestinal microbiome dysbiosis may result in harmful effects on the host, including those caused by inflammatory bowel diseases (IBD). The novel probiotic BIOHM, consisting of Bifidobacterium breve, Saccharomyces boulardii, Lactobacillus acidophilus, L. rhamnosus, and amylase, was developed t...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928933/ https://www.ncbi.nlm.nih.gov/pubmed/34940122 http://dx.doi.org/10.3390/cimb43030148 |
_version_ | 1784670745651052544 |
---|---|
author | Ghannoum, Mahmoud A. McCormick, Thomas S. Retuerto, Mauricio Bebek, Gurkan Cousineau, Susan Hartman, Lynn Barth, Charles Schrom, Kory |
author_facet | Ghannoum, Mahmoud A. McCormick, Thomas S. Retuerto, Mauricio Bebek, Gurkan Cousineau, Susan Hartman, Lynn Barth, Charles Schrom, Kory |
author_sort | Ghannoum, Mahmoud A. |
collection | PubMed |
description | Gastrointestinal microbiome dysbiosis may result in harmful effects on the host, including those caused by inflammatory bowel diseases (IBD). The novel probiotic BIOHM, consisting of Bifidobacterium breve, Saccharomyces boulardii, Lactobacillus acidophilus, L. rhamnosus, and amylase, was developed to rebalance the bacterial–fungal gut microbiome, with the goal of reducing inflammation and maintaining a healthy gut population. To test the effect of BIOHM on human subjects, we enrolled a cohort of 49 volunteers in collaboration with the Fermentation Festival group (Santa Barbara, CA, USA). The profiles of gut bacterial and fungal communities were assessed via stool samples collected at baseline and following 4 weeks of once-a-day BIOHM consumption. Mycobiome analysis following probiotic consumption revealed an increase in Ascomycota levels in enrolled individuals and a reduction in Zygomycota levels (p value < 0.01). No statistically significant difference in Basidiomycota was detected between pre- and post-BIOHM samples and control abundance profiles (p > 0.05). BIOHM consumption led to a significant reduction in the abundance of Candida genus in tested subjects (p value < 0.013), while the abundance of C. albicans also trended lower than before BIOHM use, albeit not reaching statistical significance. A reduction in the abundance of Firmicutes at the phylum level was observed following BIOHM use, which approached levels reported for control individuals reported in the Human Microbiome Project data. The preliminary results from this clinical study suggest that BIOHM is capable of significantly rebalancing the bacteriome and mycobiome in the gut of healthy individuals, suggesting that further trials examining the utility of the BIOHM probiotic in individuals with gastrointestinal symptoms, where dysbiosis is considered a source driving pathogenesis, are warranted. |
format | Online Article Text |
id | pubmed-8928933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89289332022-06-04 Evaluation of Microbiome Alterations Following Consumption of BIOHM, a Novel Probiotic Ghannoum, Mahmoud A. McCormick, Thomas S. Retuerto, Mauricio Bebek, Gurkan Cousineau, Susan Hartman, Lynn Barth, Charles Schrom, Kory Curr Issues Mol Biol Article Gastrointestinal microbiome dysbiosis may result in harmful effects on the host, including those caused by inflammatory bowel diseases (IBD). The novel probiotic BIOHM, consisting of Bifidobacterium breve, Saccharomyces boulardii, Lactobacillus acidophilus, L. rhamnosus, and amylase, was developed to rebalance the bacterial–fungal gut microbiome, with the goal of reducing inflammation and maintaining a healthy gut population. To test the effect of BIOHM on human subjects, we enrolled a cohort of 49 volunteers in collaboration with the Fermentation Festival group (Santa Barbara, CA, USA). The profiles of gut bacterial and fungal communities were assessed via stool samples collected at baseline and following 4 weeks of once-a-day BIOHM consumption. Mycobiome analysis following probiotic consumption revealed an increase in Ascomycota levels in enrolled individuals and a reduction in Zygomycota levels (p value < 0.01). No statistically significant difference in Basidiomycota was detected between pre- and post-BIOHM samples and control abundance profiles (p > 0.05). BIOHM consumption led to a significant reduction in the abundance of Candida genus in tested subjects (p value < 0.013), while the abundance of C. albicans also trended lower than before BIOHM use, albeit not reaching statistical significance. A reduction in the abundance of Firmicutes at the phylum level was observed following BIOHM use, which approached levels reported for control individuals reported in the Human Microbiome Project data. The preliminary results from this clinical study suggest that BIOHM is capable of significantly rebalancing the bacteriome and mycobiome in the gut of healthy individuals, suggesting that further trials examining the utility of the BIOHM probiotic in individuals with gastrointestinal symptoms, where dysbiosis is considered a source driving pathogenesis, are warranted. MDPI 2021-11-29 /pmc/articles/PMC8928933/ /pubmed/34940122 http://dx.doi.org/10.3390/cimb43030148 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ghannoum, Mahmoud A. McCormick, Thomas S. Retuerto, Mauricio Bebek, Gurkan Cousineau, Susan Hartman, Lynn Barth, Charles Schrom, Kory Evaluation of Microbiome Alterations Following Consumption of BIOHM, a Novel Probiotic |
title | Evaluation of Microbiome Alterations Following Consumption of BIOHM, a Novel Probiotic |
title_full | Evaluation of Microbiome Alterations Following Consumption of BIOHM, a Novel Probiotic |
title_fullStr | Evaluation of Microbiome Alterations Following Consumption of BIOHM, a Novel Probiotic |
title_full_unstemmed | Evaluation of Microbiome Alterations Following Consumption of BIOHM, a Novel Probiotic |
title_short | Evaluation of Microbiome Alterations Following Consumption of BIOHM, a Novel Probiotic |
title_sort | evaluation of microbiome alterations following consumption of biohm, a novel probiotic |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928933/ https://www.ncbi.nlm.nih.gov/pubmed/34940122 http://dx.doi.org/10.3390/cimb43030148 |
work_keys_str_mv | AT ghannoummahmouda evaluationofmicrobiomealterationsfollowingconsumptionofbiohmanovelprobiotic AT mccormickthomass evaluationofmicrobiomealterationsfollowingconsumptionofbiohmanovelprobiotic AT retuertomauricio evaluationofmicrobiomealterationsfollowingconsumptionofbiohmanovelprobiotic AT bebekgurkan evaluationofmicrobiomealterationsfollowingconsumptionofbiohmanovelprobiotic AT cousineaususan evaluationofmicrobiomealterationsfollowingconsumptionofbiohmanovelprobiotic AT hartmanlynn evaluationofmicrobiomealterationsfollowingconsumptionofbiohmanovelprobiotic AT barthcharles evaluationofmicrobiomealterationsfollowingconsumptionofbiohmanovelprobiotic AT schromkory evaluationofmicrobiomealterationsfollowingconsumptionofbiohmanovelprobiotic |