Cargando…

Functional Screenings Identify Regulatory Variants Associated with Breast Cancer Susceptibility

Genome-wide association studies (GWAS) have identified more than 2000 single nucleotide polymorphisms (SNPs) associated with breast cancer susceptibility, most of which are located in the non-coding region. However, the causal SNPs functioning as gene regulatory elements still remain largely undiscl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ren, Naixia, Li, Yingying, Xiong, Yulong, Li, Panfeng, Ren, Yutian, Huang, Qilai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928974/ https://www.ncbi.nlm.nih.gov/pubmed/34889888 http://dx.doi.org/10.3390/cimb43030124

Ejemplares similares

Parallel Reporter Assays Identify Altered Regulatory Role of rs684232 in Leading to Prostate Cancer Predisposition
por: Ren, Naixia, et al.
Publicado: (2021)

rs10514231 Leads to Breast Cancer Predisposition by Altering ATP6AP1L Gene Expression
por: Ma, Shumin, et al.
Publicado: (2021)

A qPCR method for genome editing efficiency determination and single-cell clone screening in human cells
por: Li, Bo, et al.
Publicado: (2019)

The identification of two regulatory ESCC susceptibility genetic variants in the TERT-CLPTM1L loci
por: Zhou, Liqing, et al.
Publicado: (2015)

Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants
por: Chen, Rui, et al.
Publicado: (2022)

A Systematic Screening of ADHD-Susceptible Variants From 25 Chinese Parents–Offspring Trios
por: Li, Qianqian, et al.
Publicado: (2022)

High throughput PRIME editing screens identify functional DNA variants in the human genome
por: Ren, Xingjie, et al.
Publicado: (2023)

Identification of regulatory variants associated with genetic susceptibility to meningococcal disease
por: Borghini, Lisa, et al.
Publicado: (2019)

Screening for functional transcriptional and splicing regulatory variants with GenIE
por: Cooper, Sarah E, et al.
Publicado: (2020)

Tensile mechanical performance of Ni–Co alloy nanowires by molecular dynamics simulation
por: Lu, Xuefeng, et al.
Publicado: (2019)

A Functional Variant rs2072915 is Associated with the Susceptibility and Mortality of Cervical Squamous Cell Carcinoma
por: Li, Ren-Liang, et al.
Publicado: (2021)

Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants
por: Chen, Rui, et al.
Publicado: (2022)

Identifying genetic regulatory variants that affect transcription factor activity
por: Li, Xiaoting, et al.
Publicado: (2023)

Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk
por: Wilcox, Naomi, et al.
Publicado: (2023)

Functional BCL-2 regulatory genetic variants contribute to susceptibility of esophageal squamous cell carcinoma
por: Pan, Wenting, et al.
Publicado: (2015)

Distance and Helical Phase Dependence of Synergistic Transcription Activation in cis-Regulatory Module
por: Huang, Qilai, et al.
Publicado: (2012)

Association analysis identifies ZNF750 regulatory variants in psoriasis
por: Birnbaum, Ramon Y, et al.
Publicado: (2011)

Screening for functional regulatory variants in open chromatin using GenIE-ATAC
por: Cooper, Sarah, et al.
Publicado: (2023)

Association of multiple genetic variants with breast cancer susceptibility in the Han Chinese population
por: Li, Xu, et al.
Publicado: (2016)

Exome sequencing identified rare recurrent copy number variants and hereditary breast cancer susceptibility
por: Kumpula, Timo A., et al.
Publicado: (2023)

Functional promoter -765 G > C variant in COX-2 gene is associated with the susceptibility of breast cancer in Chinese Han women
por: Gao, Jie, et al.
Publicado: (2014)

A post-GWAS analysis of predicted regulatory variants and tuberculosis susceptibility
por: Uren, Caitlin, et al.
Publicado: (2017)

Erratum: Functional BCL-2 regulatory genetic variants contribute to susceptibility of esophageal squamous cell carcinoma
por: Pan, Wenting, et al.
Publicado: (2015)

Discovery and Functional Characterization of Two Regulatory Variants Underlying Lupus Susceptibility at 2p13.1
por: Fazel-Najafabadi, Mehdi, et al.
Publicado: (2022)

Genetic Variants of CD209 Associated with Kawasaki Disease Susceptibility
por: Kuo, Ho-Chang, et al.
Publicado: (2014)

Putative functional variants of lncRNA identified by RegulomeDB were associated with knee osteoarthritis susceptibility
por: Wang, Kejie, et al.
Publicado: (2018)

Whole-exome sequencing of BRCA-negative breast cancer patients and case–control analyses identify variants associated with breast cancer susceptibility
por: Lee, Ning Yuan, et al.
Publicado: (2022)

Association of a common genetic variant in RNASEL and prostate cancer susceptibility
por: Zuo, Li, et al.
Publicado: (2017)

Screening and optimization of phage display cyclic peptides against the WDR5 WBM site
por: Song, Lingyu, et al.
Publicado: (2023)

Author Correction: Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk
por: Wilcox, Naomi, et al.
Publicado: (2023)

Variants in the ATM gene and breast cancer susceptibility
por: Milne, Roger L
Publicado: (2009)

Whole-exome sequencing analysis identifies novel variants associated with Kawasaki disease susceptibility
por: Zhang, Xing, et al.
Publicado: (2023)

Breast cancer risks associated with missense variants in breast cancer susceptibility genes
por: Dorling, Leila, et al.
Publicado: (2022)

Potentially Functional Variants of PLCE1 Identified by GWASs Contribute to Gastric Adenocarcinoma Susceptibility in an Eastern Chinese Population
por: Wang, Mengyun, et al.
Publicado: (2012)

Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms
por: Liu, Xiuxiu, et al.
Publicado: (2023)

Genetic Variants in the Transcriptional Regulatory Region of the ALOX5AP gene and Susceptibility to Ischemic Stroke in Chinese Populations
por: Yang, Dongzhi, et al.
Publicado: (2016)

An Integrated Approach to Identifying Cis-Regulatory Modules in the Human Genome
por: Won, Kyoung-Jae, et al.
Publicado: (2009)

Correction: Whole-exome sequencing of BRCA-negative breast cancer patients and case–control analyses identify variants associated with breast cancer susceptibility
por: Lee, Ning Yuan, et al.
Publicado: (2022)

Genome-wide Meta-analysis Identifies Variants Associated with Platinating Agent Susceptibility Across Populations
por: Wheeler, Heather E., et al.
Publicado: (2011)

Functional Variants in Linc-ROR are Associated with mRNA Expression of Linc-ROR and Breast Cancer Susceptibility
por: Luo, Chenglin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_qlr2td9n7dr5mkmb3qihk3h7bt