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Possibility of SARS-CoV-2 Infection in the Metastatic Microenvironment of Cancer

According to a report from the World Health Organization (WHO), the mortality and disease severity induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are significantly higher in cancer patients than those of individuals with no known condition. Common and cancer-specific ris...

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Autores principales: Hayashi, Takuma, Sano, Kenji, Konishi, Ikuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929006/
https://www.ncbi.nlm.nih.gov/pubmed/35723396
http://dx.doi.org/10.3390/cimb44010017
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author Hayashi, Takuma
Sano, Kenji
Konishi, Ikuo
author_facet Hayashi, Takuma
Sano, Kenji
Konishi, Ikuo
author_sort Hayashi, Takuma
collection PubMed
description According to a report from the World Health Organization (WHO), the mortality and disease severity induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are significantly higher in cancer patients than those of individuals with no known condition. Common and cancer-specific risk factors might be involved in the mortality and severity rates observed in the coronavirus disease 2019 (COVID-19). Similarly, various factors might contribute to the aggravation of COVID-19 in patients with cancer. However, the factors involved in the aggravation of COVID-19 in cancer patients have not been fully investigated so far. The formation of metastases in other organs is common in cancer patients. Therefore, the present study investigated the association between lung metastatic lesion formation and SARS-CoV-2 infectivity. In the pulmonary micrometastatic niche of patients with ovarian cancer, alveolar epithelial stem-like cells were found adjacent to ovarian cancer. Moreover, angiotensin-converting enzyme 2, a host-side receptor for SARS-CoV-2, was expressed in these alveolar epithelial stem-like cells. Furthermore, the spike glycoprotein receptor-binding domain (RBD) of SARS-CoV-2 was bound to alveolar epithelial stem-like cells. Altogether, these data suggested that patients with cancer and pulmonary micrometastases are more susceptible to SARS-CoV-2. The prevention of de novo niche formation in metastatic diseases might constitute a new strategy for the clinical treatment of COVID-19 for patients with cancer.
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spelling pubmed-89290062022-06-04 Possibility of SARS-CoV-2 Infection in the Metastatic Microenvironment of Cancer Hayashi, Takuma Sano, Kenji Konishi, Ikuo Curr Issues Mol Biol Communication According to a report from the World Health Organization (WHO), the mortality and disease severity induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are significantly higher in cancer patients than those of individuals with no known condition. Common and cancer-specific risk factors might be involved in the mortality and severity rates observed in the coronavirus disease 2019 (COVID-19). Similarly, various factors might contribute to the aggravation of COVID-19 in patients with cancer. However, the factors involved in the aggravation of COVID-19 in cancer patients have not been fully investigated so far. The formation of metastases in other organs is common in cancer patients. Therefore, the present study investigated the association between lung metastatic lesion formation and SARS-CoV-2 infectivity. In the pulmonary micrometastatic niche of patients with ovarian cancer, alveolar epithelial stem-like cells were found adjacent to ovarian cancer. Moreover, angiotensin-converting enzyme 2, a host-side receptor for SARS-CoV-2, was expressed in these alveolar epithelial stem-like cells. Furthermore, the spike glycoprotein receptor-binding domain (RBD) of SARS-CoV-2 was bound to alveolar epithelial stem-like cells. Altogether, these data suggested that patients with cancer and pulmonary micrometastases are more susceptible to SARS-CoV-2. The prevention of de novo niche formation in metastatic diseases might constitute a new strategy for the clinical treatment of COVID-19 for patients with cancer. MDPI 2022-01-05 /pmc/articles/PMC8929006/ /pubmed/35723396 http://dx.doi.org/10.3390/cimb44010017 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Hayashi, Takuma
Sano, Kenji
Konishi, Ikuo
Possibility of SARS-CoV-2 Infection in the Metastatic Microenvironment of Cancer
title Possibility of SARS-CoV-2 Infection in the Metastatic Microenvironment of Cancer
title_full Possibility of SARS-CoV-2 Infection in the Metastatic Microenvironment of Cancer
title_fullStr Possibility of SARS-CoV-2 Infection in the Metastatic Microenvironment of Cancer
title_full_unstemmed Possibility of SARS-CoV-2 Infection in the Metastatic Microenvironment of Cancer
title_short Possibility of SARS-CoV-2 Infection in the Metastatic Microenvironment of Cancer
title_sort possibility of sars-cov-2 infection in the metastatic microenvironment of cancer
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929006/
https://www.ncbi.nlm.nih.gov/pubmed/35723396
http://dx.doi.org/10.3390/cimb44010017
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