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Immunomodulatory Expression of Cathelicidins Peptides in Pulp Inflammation and Regeneration: An Update
The role of inflammatory mediators in dental pulp is unique. The local environment of pulp responds to any changes in the physiology that are highly fundamental, like odontoblast cell differentiation and other secretory activity. The aim of this review is to assess the role of cathelicidins based on...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929016/ https://www.ncbi.nlm.nih.gov/pubmed/34068275 http://dx.doi.org/10.3390/cimb43010010 |
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author | Nireeksha, Varma, Sudhir Rama Damdoum, Marah Alsaegh, Mohammed Amjed Hegde, Mithra N. Kumari, Suchetha N. Ramamurthy, Srinivasan Narayanan, Jayaraj Imran, Eisha Shabbir, Juzer Khurshid, Zohaib |
author_facet | Nireeksha, Varma, Sudhir Rama Damdoum, Marah Alsaegh, Mohammed Amjed Hegde, Mithra N. Kumari, Suchetha N. Ramamurthy, Srinivasan Narayanan, Jayaraj Imran, Eisha Shabbir, Juzer Khurshid, Zohaib |
author_sort | Nireeksha, |
collection | PubMed |
description | The role of inflammatory mediators in dental pulp is unique. The local environment of pulp responds to any changes in the physiology that are highly fundamental, like odontoblast cell differentiation and other secretory activity. The aim of this review is to assess the role of cathelicidins based on their capacity to heal wounds, their immunomodulatory potential, and their ability to stimulate cytokine production and stimulate immune-inflammatory response in pulp and periapex. Accessible electronic databases were searched to find studies reporting the role of cathelicidins in pulpal inflammation and regeneration published between September 2010 and September 2020. The search was performed using the following databases: Medline, Scopus, Web of Science, SciELO and PubMed. The electronic search was performed using the combination of keywords “cathelicidins” and “dental pulp inflammation”. On the basis of previous studies, it can be inferred that LL-37 plays an important role in odontoblastic cell differentiation and stimulation of antimicrobial peptides. Furthermore, based on these outcomes, it can be concluded that LL-37 plays an important role in reparative dentin formation and provides signaling for defense by activating the innate immune system. |
format | Online Article Text |
id | pubmed-8929016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89290162022-06-04 Immunomodulatory Expression of Cathelicidins Peptides in Pulp Inflammation and Regeneration: An Update Nireeksha, Varma, Sudhir Rama Damdoum, Marah Alsaegh, Mohammed Amjed Hegde, Mithra N. Kumari, Suchetha N. Ramamurthy, Srinivasan Narayanan, Jayaraj Imran, Eisha Shabbir, Juzer Khurshid, Zohaib Curr Issues Mol Biol Review The role of inflammatory mediators in dental pulp is unique. The local environment of pulp responds to any changes in the physiology that are highly fundamental, like odontoblast cell differentiation and other secretory activity. The aim of this review is to assess the role of cathelicidins based on their capacity to heal wounds, their immunomodulatory potential, and their ability to stimulate cytokine production and stimulate immune-inflammatory response in pulp and periapex. Accessible electronic databases were searched to find studies reporting the role of cathelicidins in pulpal inflammation and regeneration published between September 2010 and September 2020. The search was performed using the following databases: Medline, Scopus, Web of Science, SciELO and PubMed. The electronic search was performed using the combination of keywords “cathelicidins” and “dental pulp inflammation”. On the basis of previous studies, it can be inferred that LL-37 plays an important role in odontoblastic cell differentiation and stimulation of antimicrobial peptides. Furthermore, based on these outcomes, it can be concluded that LL-37 plays an important role in reparative dentin formation and provides signaling for defense by activating the innate immune system. MDPI 2021-05-13 /pmc/articles/PMC8929016/ /pubmed/34068275 http://dx.doi.org/10.3390/cimb43010010 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nireeksha, Varma, Sudhir Rama Damdoum, Marah Alsaegh, Mohammed Amjed Hegde, Mithra N. Kumari, Suchetha N. Ramamurthy, Srinivasan Narayanan, Jayaraj Imran, Eisha Shabbir, Juzer Khurshid, Zohaib Immunomodulatory Expression of Cathelicidins Peptides in Pulp Inflammation and Regeneration: An Update |
title | Immunomodulatory Expression of Cathelicidins Peptides in Pulp Inflammation and Regeneration: An Update |
title_full | Immunomodulatory Expression of Cathelicidins Peptides in Pulp Inflammation and Regeneration: An Update |
title_fullStr | Immunomodulatory Expression of Cathelicidins Peptides in Pulp Inflammation and Regeneration: An Update |
title_full_unstemmed | Immunomodulatory Expression of Cathelicidins Peptides in Pulp Inflammation and Regeneration: An Update |
title_short | Immunomodulatory Expression of Cathelicidins Peptides in Pulp Inflammation and Regeneration: An Update |
title_sort | immunomodulatory expression of cathelicidins peptides in pulp inflammation and regeneration: an update |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929016/ https://www.ncbi.nlm.nih.gov/pubmed/34068275 http://dx.doi.org/10.3390/cimb43010010 |
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