Effect of Ducrosia flabellifolia and Savignya parviflora Extracts on Inhibition of Human Colon and Prostate Cancer Cell Lines

The goal of this study was to investigate whether Ducrosia flabellifolia and Savignya parviflora methanol extract the have effect on colon and prostate cancer cell lines. Analysis of total content of phenolics and flavonoids of each plant extract was carried out. Cytotoxic effect, cell cycle analysi...

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Autores principales: Alghamdi, Youssef Saeed, Saleh, Osama Moseilhy, Alqadri, Nada, Mashraqi, Mutaib Mosaued, Bahattab, Omar, Awad, Nabil Saied
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929105/
https://www.ncbi.nlm.nih.gov/pubmed/34698080
http://dx.doi.org/10.3390/cimb43030107
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author Alghamdi, Youssef Saeed
Saleh, Osama Moseilhy
Alqadri, Nada
Mashraqi, Mutaib Mosaued
Bahattab, Omar
Awad, Nabil Saied
author_facet Alghamdi, Youssef Saeed
Saleh, Osama Moseilhy
Alqadri, Nada
Mashraqi, Mutaib Mosaued
Bahattab, Omar
Awad, Nabil Saied
author_sort Alghamdi, Youssef Saeed
collection PubMed
description The goal of this study was to investigate whether Ducrosia flabellifolia and Savignya parviflora methanol extract the have effect on colon and prostate cancer cell lines. Analysis of total content of phenolics and flavonoids of each plant extract was carried out. Cytotoxic effect, cell cycle analysis, induction of apoptosis and gene expression of Bcl-2 and Bax genes were studied. Obtained results indicated that, the plant extracts exhibit growth inhibition of used cancer cell lines and induced apoptosis as well as arresting of cell cycle. At the molecular level, changes in gene expression were detected via qPCR and confirmed by western blotting. The exhibited anticancer potentialities of plant extracts against utilized cancer cell lines are due to its containing bioactive compounds. Further detailed isolation, fractionation and characterization of bioactive compounds are needed.
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spelling pubmed-89291052022-06-04 Effect of Ducrosia flabellifolia and Savignya parviflora Extracts on Inhibition of Human Colon and Prostate Cancer Cell Lines Alghamdi, Youssef Saeed Saleh, Osama Moseilhy Alqadri, Nada Mashraqi, Mutaib Mosaued Bahattab, Omar Awad, Nabil Saied Curr Issues Mol Biol Article The goal of this study was to investigate whether Ducrosia flabellifolia and Savignya parviflora methanol extract the have effect on colon and prostate cancer cell lines. Analysis of total content of phenolics and flavonoids of each plant extract was carried out. Cytotoxic effect, cell cycle analysis, induction of apoptosis and gene expression of Bcl-2 and Bax genes were studied. Obtained results indicated that, the plant extracts exhibit growth inhibition of used cancer cell lines and induced apoptosis as well as arresting of cell cycle. At the molecular level, changes in gene expression were detected via qPCR and confirmed by western blotting. The exhibited anticancer potentialities of plant extracts against utilized cancer cell lines are due to its containing bioactive compounds. Further detailed isolation, fractionation and characterization of bioactive compounds are needed. MDPI 2021-10-10 /pmc/articles/PMC8929105/ /pubmed/34698080 http://dx.doi.org/10.3390/cimb43030107 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alghamdi, Youssef Saeed
Saleh, Osama Moseilhy
Alqadri, Nada
Mashraqi, Mutaib Mosaued
Bahattab, Omar
Awad, Nabil Saied
Effect of Ducrosia flabellifolia and Savignya parviflora Extracts on Inhibition of Human Colon and Prostate Cancer Cell Lines
title Effect of Ducrosia flabellifolia and Savignya parviflora Extracts on Inhibition of Human Colon and Prostate Cancer Cell Lines
title_full Effect of Ducrosia flabellifolia and Savignya parviflora Extracts on Inhibition of Human Colon and Prostate Cancer Cell Lines
title_fullStr Effect of Ducrosia flabellifolia and Savignya parviflora Extracts on Inhibition of Human Colon and Prostate Cancer Cell Lines
title_full_unstemmed Effect of Ducrosia flabellifolia and Savignya parviflora Extracts on Inhibition of Human Colon and Prostate Cancer Cell Lines
title_short Effect of Ducrosia flabellifolia and Savignya parviflora Extracts on Inhibition of Human Colon and Prostate Cancer Cell Lines
title_sort effect of ducrosia flabellifolia and savignya parviflora extracts on inhibition of human colon and prostate cancer cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929105/
https://www.ncbi.nlm.nih.gov/pubmed/34698080
http://dx.doi.org/10.3390/cimb43030107
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