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Temporal Modulation of Drug Desensitization Procedures
Drug hypersensitivity reactions are an unavoidable clinical consequence of the presence of new therapeutic agents. These adverse reactions concern patients afflicted with infectious diseases (e.g., hypersensitivity to antibiotics), and with non-infectious chronic diseases, such as in cancers, diabet...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929139/ https://www.ncbi.nlm.nih.gov/pubmed/35723342 http://dx.doi.org/10.3390/cimb44020057 |
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author | Stan, Razvan Costin |
author_facet | Stan, Razvan Costin |
author_sort | Stan, Razvan Costin |
collection | PubMed |
description | Drug hypersensitivity reactions are an unavoidable clinical consequence of the presence of new therapeutic agents. These adverse reactions concern patients afflicted with infectious diseases (e.g., hypersensitivity to antibiotics), and with non-infectious chronic diseases, such as in cancers, diabetes or cystic fibrosis treatments, and may occur at the first drug administration or after repeated exposures. Here we revise recent key studies on the mechanisms underlying the desensitization protocols, and propose an additional temporal regulation layer that is based on the circadian control of the signaling pathway involved and on the modulation of the memory effects established by the desensitization procedures. |
format | Online Article Text |
id | pubmed-8929139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89291392022-06-04 Temporal Modulation of Drug Desensitization Procedures Stan, Razvan Costin Curr Issues Mol Biol Review Drug hypersensitivity reactions are an unavoidable clinical consequence of the presence of new therapeutic agents. These adverse reactions concern patients afflicted with infectious diseases (e.g., hypersensitivity to antibiotics), and with non-infectious chronic diseases, such as in cancers, diabetes or cystic fibrosis treatments, and may occur at the first drug administration or after repeated exposures. Here we revise recent key studies on the mechanisms underlying the desensitization protocols, and propose an additional temporal regulation layer that is based on the circadian control of the signaling pathway involved and on the modulation of the memory effects established by the desensitization procedures. MDPI 2022-02-08 /pmc/articles/PMC8929139/ /pubmed/35723342 http://dx.doi.org/10.3390/cimb44020057 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Stan, Razvan Costin Temporal Modulation of Drug Desensitization Procedures |
title | Temporal Modulation of Drug Desensitization Procedures |
title_full | Temporal Modulation of Drug Desensitization Procedures |
title_fullStr | Temporal Modulation of Drug Desensitization Procedures |
title_full_unstemmed | Temporal Modulation of Drug Desensitization Procedures |
title_short | Temporal Modulation of Drug Desensitization Procedures |
title_sort | temporal modulation of drug desensitization procedures |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929139/ https://www.ncbi.nlm.nih.gov/pubmed/35723342 http://dx.doi.org/10.3390/cimb44020057 |
work_keys_str_mv | AT stanrazvancostin temporalmodulationofdrugdesensitizationprocedures |