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A Case of Angioimmunoblastic T-cell Lymphoma Hidden in Plain Sight: A Delay in Diagnosis and Management

Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon type of cluster of differentiation (CD)4 T-cell peripheral lymphoma. The varied clinical presentations of AITL present a challenge for accurate diagnosis. We present a case of a 57-year-old female with a history of severe acute respiratory syn...

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Autores principales: Udongwo, Ndausung, Fareen, Nusha, Fried, Hayley, Nessim, Jennifer, Narra, Lakshmi Rehka, Gor, Dhairya, Gupta, Varsha, Farooq, Narmeen, Chaughtai, Saira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929205/
https://www.ncbi.nlm.nih.gov/pubmed/35356395
http://dx.doi.org/10.14740/jmc3890
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author Udongwo, Ndausung
Fareen, Nusha
Fried, Hayley
Nessim, Jennifer
Narra, Lakshmi Rehka
Gor, Dhairya
Gupta, Varsha
Farooq, Narmeen
Chaughtai, Saira
author_facet Udongwo, Ndausung
Fareen, Nusha
Fried, Hayley
Nessim, Jennifer
Narra, Lakshmi Rehka
Gor, Dhairya
Gupta, Varsha
Farooq, Narmeen
Chaughtai, Saira
author_sort Udongwo, Ndausung
collection PubMed
description Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon type of cluster of differentiation (CD)4 T-cell peripheral lymphoma. The varied clinical presentations of AITL present a challenge for accurate diagnosis. We present a case of a 57-year-old female with a history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in May 2020, who presented to the hospital in the summer of 2021 with shortness of breath for 3 months. She underwent an extensive workup for lymphadenopathy while in Canada involving multiple core lymph node biopsies, which were inconclusive. Here in our institution, several tests for infectious diseases were unremarkable. Imaging tests revealed bilateral pleural effusion, lymphadenopathies, and rectal thickening. Results from rectal biopsy and excisional cervical lymph node biopsy revealed findings typical of AITL. Due to worsening hypoxia with pleural fluid accumulation, bilateral chest tubes (PleurX catheter) were placed. Steroids and chemotherapy were started. She was discharged in stable condition to follow-up care. An integrated and persistent approach comprising clinical, morphologic, excisional biopsy, immunophenotyping, and molecular tests is essential in reaching a correct diagnosis of AITL. Through our consistent effort to obtain further imaging and tissue biopsies, we came to the diagnosis which allowed her to begin appropriate life-saving treatments.
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spelling pubmed-89292052022-03-29 A Case of Angioimmunoblastic T-cell Lymphoma Hidden in Plain Sight: A Delay in Diagnosis and Management Udongwo, Ndausung Fareen, Nusha Fried, Hayley Nessim, Jennifer Narra, Lakshmi Rehka Gor, Dhairya Gupta, Varsha Farooq, Narmeen Chaughtai, Saira J Med Cases Case Report Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon type of cluster of differentiation (CD)4 T-cell peripheral lymphoma. The varied clinical presentations of AITL present a challenge for accurate diagnosis. We present a case of a 57-year-old female with a history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in May 2020, who presented to the hospital in the summer of 2021 with shortness of breath for 3 months. She underwent an extensive workup for lymphadenopathy while in Canada involving multiple core lymph node biopsies, which were inconclusive. Here in our institution, several tests for infectious diseases were unremarkable. Imaging tests revealed bilateral pleural effusion, lymphadenopathies, and rectal thickening. Results from rectal biopsy and excisional cervical lymph node biopsy revealed findings typical of AITL. Due to worsening hypoxia with pleural fluid accumulation, bilateral chest tubes (PleurX catheter) were placed. Steroids and chemotherapy were started. She was discharged in stable condition to follow-up care. An integrated and persistent approach comprising clinical, morphologic, excisional biopsy, immunophenotyping, and molecular tests is essential in reaching a correct diagnosis of AITL. Through our consistent effort to obtain further imaging and tissue biopsies, we came to the diagnosis which allowed her to begin appropriate life-saving treatments. Elmer Press 2022-03 2022-03-05 /pmc/articles/PMC8929205/ /pubmed/35356395 http://dx.doi.org/10.14740/jmc3890 Text en Copyright 2022, Udongwo et al. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Udongwo, Ndausung
Fareen, Nusha
Fried, Hayley
Nessim, Jennifer
Narra, Lakshmi Rehka
Gor, Dhairya
Gupta, Varsha
Farooq, Narmeen
Chaughtai, Saira
A Case of Angioimmunoblastic T-cell Lymphoma Hidden in Plain Sight: A Delay in Diagnosis and Management
title A Case of Angioimmunoblastic T-cell Lymphoma Hidden in Plain Sight: A Delay in Diagnosis and Management
title_full A Case of Angioimmunoblastic T-cell Lymphoma Hidden in Plain Sight: A Delay in Diagnosis and Management
title_fullStr A Case of Angioimmunoblastic T-cell Lymphoma Hidden in Plain Sight: A Delay in Diagnosis and Management
title_full_unstemmed A Case of Angioimmunoblastic T-cell Lymphoma Hidden in Plain Sight: A Delay in Diagnosis and Management
title_short A Case of Angioimmunoblastic T-cell Lymphoma Hidden in Plain Sight: A Delay in Diagnosis and Management
title_sort case of angioimmunoblastic t-cell lymphoma hidden in plain sight: a delay in diagnosis and management
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929205/
https://www.ncbi.nlm.nih.gov/pubmed/35356395
http://dx.doi.org/10.14740/jmc3890
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