Cargando…

Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients

Accelerated brain aging had been widely reported in patients with schizophrenia (SZ). However, brain aging trajectories in SZ patients have not been well-documented using three-modal magnetic resonance imaging (MRI) data. In this study, 138 schizophrenia patients and 205 normal controls aged 20–60 w...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Jiayuan, Ke, Pengfei, Chen, Xiaoyi, Li, Shijia, Zhou, Jing, Xiong, Dongsheng, Huang, Yuanyuan, Li, Hehua, Ning, Yuping, Duan, Xujun, Li, Xiaobo, Zhang, Wensheng, Wu, Fengchun, Wu, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929292/
https://www.ncbi.nlm.nih.gov/pubmed/35309897
http://dx.doi.org/10.3389/fnagi.2022.823502
_version_ 1784670832597925888
author Huang, Jiayuan
Ke, Pengfei
Chen, Xiaoyi
Li, Shijia
Zhou, Jing
Xiong, Dongsheng
Huang, Yuanyuan
Li, Hehua
Ning, Yuping
Duan, Xujun
Li, Xiaobo
Zhang, Wensheng
Wu, Fengchun
Wu, Kai
author_facet Huang, Jiayuan
Ke, Pengfei
Chen, Xiaoyi
Li, Shijia
Zhou, Jing
Xiong, Dongsheng
Huang, Yuanyuan
Li, Hehua
Ning, Yuping
Duan, Xujun
Li, Xiaobo
Zhang, Wensheng
Wu, Fengchun
Wu, Kai
author_sort Huang, Jiayuan
collection PubMed
description Accelerated brain aging had been widely reported in patients with schizophrenia (SZ). However, brain aging trajectories in SZ patients have not been well-documented using three-modal magnetic resonance imaging (MRI) data. In this study, 138 schizophrenia patients and 205 normal controls aged 20–60 were included and multimodal MRI data were acquired for each individual, including structural MRI, resting state-functional MRI and diffusion tensor imaging. The brain age of each participant was estimated by features extracted from multimodal MRI data using linear multiple regression. The correlation between the brain age gap and chronological age in SZ patients was best fitted by a positive quadratic curve with a peak chronological age of 47.33 years. We used the peak to divide the subjects into a youth group and a middle age group. In the normal controls, brain age matched chronological age well for both the youth and middle age groups, but this was not the case for schizophrenia patients. More importantly, schizophrenia patients exhibited increased brain age in the youth group but not in the middle age group. In this study, we aimed to investigate brain aging trajectories in SZ patients using multimodal MRI data and revealed an aberrant brain age trajectory in young schizophrenia patients, providing new insights into the pathophysiological mechanisms of schizophrenia.
format Online
Article
Text
id pubmed-8929292
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89292922022-03-18 Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients Huang, Jiayuan Ke, Pengfei Chen, Xiaoyi Li, Shijia Zhou, Jing Xiong, Dongsheng Huang, Yuanyuan Li, Hehua Ning, Yuping Duan, Xujun Li, Xiaobo Zhang, Wensheng Wu, Fengchun Wu, Kai Front Aging Neurosci Aging Neuroscience Accelerated brain aging had been widely reported in patients with schizophrenia (SZ). However, brain aging trajectories in SZ patients have not been well-documented using three-modal magnetic resonance imaging (MRI) data. In this study, 138 schizophrenia patients and 205 normal controls aged 20–60 were included and multimodal MRI data were acquired for each individual, including structural MRI, resting state-functional MRI and diffusion tensor imaging. The brain age of each participant was estimated by features extracted from multimodal MRI data using linear multiple regression. The correlation between the brain age gap and chronological age in SZ patients was best fitted by a positive quadratic curve with a peak chronological age of 47.33 years. We used the peak to divide the subjects into a youth group and a middle age group. In the normal controls, brain age matched chronological age well for both the youth and middle age groups, but this was not the case for schizophrenia patients. More importantly, schizophrenia patients exhibited increased brain age in the youth group but not in the middle age group. In this study, we aimed to investigate brain aging trajectories in SZ patients using multimodal MRI data and revealed an aberrant brain age trajectory in young schizophrenia patients, providing new insights into the pathophysiological mechanisms of schizophrenia. Frontiers Media S.A. 2022-03-03 /pmc/articles/PMC8929292/ /pubmed/35309897 http://dx.doi.org/10.3389/fnagi.2022.823502 Text en Copyright © 2022 Huang, Ke, Chen, Li, Zhou, Xiong, Huang, Li, Ning, Duan, Li, Zhang, Wu and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Huang, Jiayuan
Ke, Pengfei
Chen, Xiaoyi
Li, Shijia
Zhou, Jing
Xiong, Dongsheng
Huang, Yuanyuan
Li, Hehua
Ning, Yuping
Duan, Xujun
Li, Xiaobo
Zhang, Wensheng
Wu, Fengchun
Wu, Kai
Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients
title Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients
title_full Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients
title_fullStr Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients
title_full_unstemmed Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients
title_short Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients
title_sort multimodal magnetic resonance imaging reveals aberrant brain age trajectory during youth in schizophrenia patients
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929292/
https://www.ncbi.nlm.nih.gov/pubmed/35309897
http://dx.doi.org/10.3389/fnagi.2022.823502
work_keys_str_mv AT huangjiayuan multimodalmagneticresonanceimagingrevealsaberrantbrainagetrajectoryduringyouthinschizophreniapatients
AT kepengfei multimodalmagneticresonanceimagingrevealsaberrantbrainagetrajectoryduringyouthinschizophreniapatients
AT chenxiaoyi multimodalmagneticresonanceimagingrevealsaberrantbrainagetrajectoryduringyouthinschizophreniapatients
AT lishijia multimodalmagneticresonanceimagingrevealsaberrantbrainagetrajectoryduringyouthinschizophreniapatients
AT zhoujing multimodalmagneticresonanceimagingrevealsaberrantbrainagetrajectoryduringyouthinschizophreniapatients
AT xiongdongsheng multimodalmagneticresonanceimagingrevealsaberrantbrainagetrajectoryduringyouthinschizophreniapatients
AT huangyuanyuan multimodalmagneticresonanceimagingrevealsaberrantbrainagetrajectoryduringyouthinschizophreniapatients
AT lihehua multimodalmagneticresonanceimagingrevealsaberrantbrainagetrajectoryduringyouthinschizophreniapatients
AT ningyuping multimodalmagneticresonanceimagingrevealsaberrantbrainagetrajectoryduringyouthinschizophreniapatients
AT duanxujun multimodalmagneticresonanceimagingrevealsaberrantbrainagetrajectoryduringyouthinschizophreniapatients
AT lixiaobo multimodalmagneticresonanceimagingrevealsaberrantbrainagetrajectoryduringyouthinschizophreniapatients
AT zhangwensheng multimodalmagneticresonanceimagingrevealsaberrantbrainagetrajectoryduringyouthinschizophreniapatients
AT wufengchun multimodalmagneticresonanceimagingrevealsaberrantbrainagetrajectoryduringyouthinschizophreniapatients
AT wukai multimodalmagneticresonanceimagingrevealsaberrantbrainagetrajectoryduringyouthinschizophreniapatients