Application of a high‐resolution in vitro human MDR1‐MDCK assay and in vivo studies in preclinical species to improve prediction of CNS drug penetration

P‐glycoprotein (P‐gp, MDR1) is expressed at the blood–brain barrier (BBB) and restricts penetration of its substrates into the central nervous system (CNS). In vitro MDR1 assays are frequently used to predict the in vivo relevance of MDR1‐mediated efflux at the BBB. It has been well established that...

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Detalles Bibliográficos
Autores principales: Jiang, Licong, Kumar, Sanjeev, Nuechterlein, Marc, Reyes, Marissa, Tran, Dao, Cabebe, Clifford, Chiang, Peggy, Reynolds, James, Carrier, Scott, Sun, Yongkai, Eddershaw, Peter, Hay, Tanya, Chen, Weichao, Feng, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929335/
https://www.ncbi.nlm.nih.gov/pubmed/35156331
http://dx.doi.org/10.1002/prp2.932

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