Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG‐018

Neutral antagonists of GPCRs remain relatively rare—indeed, a large majority of GPCR antagonists are actually inverse agonists. The synthetic cannabinoid receptor agonist (SCRA) EG‐018 was recently reported as a low efficacy cannabinoid receptor agonist. Here we report a comparative characterization...

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Detalles Bibliográficos
Autores principales: Finlay, David B., Nguyen, Thuy, Gamage, Thomas F., Chen, Shuli, Barrus, Daniel G., Patel, Purvi R., Thomas, Brian F., Wiley, Jenny L., Zhang, Yanan, Glass, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929370/
https://www.ncbi.nlm.nih.gov/pubmed/35041297
http://dx.doi.org/10.1002/prp2.901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929370/
https://www.ncbi.nlm.nih.gov/pubmed/35041297
http://dx.doi.org/10.1002/prp2.901

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