The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity

Coronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-]gamma, is an essential cytokine in the antiviral immune resp...

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Detalles Bibliográficos
Autores principales: Rasmi, Yousef, Heidari, Nadia, Kübra Kırboğa, Kevser, Hatamkhani, Shima, Tekin, Burcu, Alipour, Shahryar, Naderi, Roya, Farnamian, Yeghaneh, Akca, Ilknur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Canadian Society of Clinical Chemists. Published by Elsevier Inc. 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929545/
https://www.ncbi.nlm.nih.gov/pubmed/35307400
http://dx.doi.org/10.1016/j.clinbiochem.2022.03.002
Descripción
Sumario:Coronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-]gamma, is an essential cytokine in the antiviral immune response. NPT has been used as a marker for the early assessment of disease severity in different diseases. The leading cause of NPT production is the pro-inflammatory cytokine IFN-. Macrophage activation has also been revealed to be linked with disease severity in SARS-CoV-2 patients. We demonstrate the importance of NPT in the pathogenesis of SARS-CoV-2 and suggest that targeting NPT in SARS-CoV-2 infection may be critical in the early prediction of disease progression and provision of timely management of infected individuals.

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