The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity

Coronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-]gamma, is an essential cytokine in the antiviral immune resp...

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Autores principales: Rasmi, Yousef, Heidari, Nadia, Kübra Kırboğa, Kevser, Hatamkhani, Shima, Tekin, Burcu, Alipour, Shahryar, Naderi, Roya, Farnamian, Yeghaneh, Akca, Ilknur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Canadian Society of Clinical Chemists. Published by Elsevier Inc. 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929545/
https://www.ncbi.nlm.nih.gov/pubmed/35307400
http://dx.doi.org/10.1016/j.clinbiochem.2022.03.002
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author Rasmi, Yousef
Heidari, Nadia
Kübra Kırboğa, Kevser
Hatamkhani, Shima
Tekin, Burcu
Alipour, Shahryar
Naderi, Roya
Farnamian, Yeghaneh
Akca, Ilknur
author_facet Rasmi, Yousef
Heidari, Nadia
Kübra Kırboğa, Kevser
Hatamkhani, Shima
Tekin, Burcu
Alipour, Shahryar
Naderi, Roya
Farnamian, Yeghaneh
Akca, Ilknur
author_sort Rasmi, Yousef
collection PubMed
description Coronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-]gamma, is an essential cytokine in the antiviral immune response. NPT has been used as a marker for the early assessment of disease severity in different diseases. The leading cause of NPT production is the pro-inflammatory cytokine IFN-. Macrophage activation has also been revealed to be linked with disease severity in SARS-CoV-2 patients. We demonstrate the importance of NPT in the pathogenesis of SARS-CoV-2 and suggest that targeting NPT in SARS-CoV-2 infection may be critical in the early prediction of disease progression and provision of timely management of infected individuals.
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spelling pubmed-89295452022-03-18 The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity Rasmi, Yousef Heidari, Nadia Kübra Kırboğa, Kevser Hatamkhani, Shima Tekin, Burcu Alipour, Shahryar Naderi, Roya Farnamian, Yeghaneh Akca, Ilknur Clin Biochem Review Coronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-]gamma, is an essential cytokine in the antiviral immune response. NPT has been used as a marker for the early assessment of disease severity in different diseases. The leading cause of NPT production is the pro-inflammatory cytokine IFN-. Macrophage activation has also been revealed to be linked with disease severity in SARS-CoV-2 patients. We demonstrate the importance of NPT in the pathogenesis of SARS-CoV-2 and suggest that targeting NPT in SARS-CoV-2 infection may be critical in the early prediction of disease progression and provision of timely management of infected individuals. The Canadian Society of Clinical Chemists. Published by Elsevier Inc. 2022-06 2022-03-17 /pmc/articles/PMC8929545/ /pubmed/35307400 http://dx.doi.org/10.1016/j.clinbiochem.2022.03.002 Text en © 2022 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Rasmi, Yousef
Heidari, Nadia
Kübra Kırboğa, Kevser
Hatamkhani, Shima
Tekin, Burcu
Alipour, Shahryar
Naderi, Roya
Farnamian, Yeghaneh
Akca, Ilknur
The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity
title The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity
title_full The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity
title_fullStr The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity
title_full_unstemmed The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity
title_short The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity
title_sort importance of neopterin in covid-19: the prognostic value and relation with the disease severity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929545/
https://www.ncbi.nlm.nih.gov/pubmed/35307400
http://dx.doi.org/10.1016/j.clinbiochem.2022.03.002
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