Cargando…

A Polydopamine-Coated Platinum Nanoplatform for Tumor-Targeted Photothermal Ablation and Migration Inhibition

In this work, Arg-Gly-Asp (RGD) peptide-coupled polydopamine-modified mesoporous platinum nanoparticles (mPt@PDA-RGD NPs) were developed for targeted photothermal therapy (PTT) and migration inhibition of SKOV-3 cells. mPt@PDA-RGD NPs with obvious core/shell structure demonstrated high photothermal...

Descripción completa

Detalles Bibliográficos
Autores principales: Zou, Xianwen, Ma, Guiqi, Zhu, Pengyu, Cao, Yutao, Sun, Xiao, Wang, Haijun, Dong, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929664/
https://www.ncbi.nlm.nih.gov/pubmed/35311136
http://dx.doi.org/10.3389/fonc.2022.860718
_version_ 1784670909696573440
author Zou, Xianwen
Ma, Guiqi
Zhu, Pengyu
Cao, Yutao
Sun, Xiao
Wang, Haijun
Dong, Jian
author_facet Zou, Xianwen
Ma, Guiqi
Zhu, Pengyu
Cao, Yutao
Sun, Xiao
Wang, Haijun
Dong, Jian
author_sort Zou, Xianwen
collection PubMed
description In this work, Arg-Gly-Asp (RGD) peptide-coupled polydopamine-modified mesoporous platinum nanoparticles (mPt@PDA-RGD NPs) were developed for targeted photothermal therapy (PTT) and migration inhibition of SKOV-3 cells. mPt@PDA-RGD NPs with obvious core/shell structure demonstrated high photothermal performance under 808-nm near-infrared (NIR) laser irradiation. mPt@PDA-RGD NPs with favorable biocompatibility exhibited remarkable SKOV-3 inhibition ability under NIR laser irradiation. Moreover, compared to mPt@PDA NPs, the RGD-functionalized NPs achieved more tumor uptake and PTT performance, which was attributed to the specific interaction between RGD of NPs and α(v)β(3) integrin overexpressed by SKOV-3. Importantly, cell scratch experiments indicated that the photothermal effect of mPt@PDA-RGD NPs can effectively inhibit the migration of surviving SKOV-3 cells, which was assigned to disturbance of the actin cytoskeleton of SKOV-3. Thus, mPt@PDA-RGD NPs presented great potential for targeted tumor photothermal ablation and migration inhibition.
format Online
Article
Text
id pubmed-8929664
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89296642022-03-18 A Polydopamine-Coated Platinum Nanoplatform for Tumor-Targeted Photothermal Ablation and Migration Inhibition Zou, Xianwen Ma, Guiqi Zhu, Pengyu Cao, Yutao Sun, Xiao Wang, Haijun Dong, Jian Front Oncol Oncology In this work, Arg-Gly-Asp (RGD) peptide-coupled polydopamine-modified mesoporous platinum nanoparticles (mPt@PDA-RGD NPs) were developed for targeted photothermal therapy (PTT) and migration inhibition of SKOV-3 cells. mPt@PDA-RGD NPs with obvious core/shell structure demonstrated high photothermal performance under 808-nm near-infrared (NIR) laser irradiation. mPt@PDA-RGD NPs with favorable biocompatibility exhibited remarkable SKOV-3 inhibition ability under NIR laser irradiation. Moreover, compared to mPt@PDA NPs, the RGD-functionalized NPs achieved more tumor uptake and PTT performance, which was attributed to the specific interaction between RGD of NPs and α(v)β(3) integrin overexpressed by SKOV-3. Importantly, cell scratch experiments indicated that the photothermal effect of mPt@PDA-RGD NPs can effectively inhibit the migration of surviving SKOV-3 cells, which was assigned to disturbance of the actin cytoskeleton of SKOV-3. Thus, mPt@PDA-RGD NPs presented great potential for targeted tumor photothermal ablation and migration inhibition. Frontiers Media S.A. 2022-03-03 /pmc/articles/PMC8929664/ /pubmed/35311136 http://dx.doi.org/10.3389/fonc.2022.860718 Text en Copyright © 2022 Zou, Ma, Zhu, Cao, Sun, Wang and Dong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zou, Xianwen
Ma, Guiqi
Zhu, Pengyu
Cao, Yutao
Sun, Xiao
Wang, Haijun
Dong, Jian
A Polydopamine-Coated Platinum Nanoplatform for Tumor-Targeted Photothermal Ablation and Migration Inhibition
title A Polydopamine-Coated Platinum Nanoplatform for Tumor-Targeted Photothermal Ablation and Migration Inhibition
title_full A Polydopamine-Coated Platinum Nanoplatform for Tumor-Targeted Photothermal Ablation and Migration Inhibition
title_fullStr A Polydopamine-Coated Platinum Nanoplatform for Tumor-Targeted Photothermal Ablation and Migration Inhibition
title_full_unstemmed A Polydopamine-Coated Platinum Nanoplatform for Tumor-Targeted Photothermal Ablation and Migration Inhibition
title_short A Polydopamine-Coated Platinum Nanoplatform for Tumor-Targeted Photothermal Ablation and Migration Inhibition
title_sort polydopamine-coated platinum nanoplatform for tumor-targeted photothermal ablation and migration inhibition
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929664/
https://www.ncbi.nlm.nih.gov/pubmed/35311136
http://dx.doi.org/10.3389/fonc.2022.860718
work_keys_str_mv AT zouxianwen apolydopaminecoatedplatinumnanoplatformfortumortargetedphotothermalablationandmigrationinhibition
AT maguiqi apolydopaminecoatedplatinumnanoplatformfortumortargetedphotothermalablationandmigrationinhibition
AT zhupengyu apolydopaminecoatedplatinumnanoplatformfortumortargetedphotothermalablationandmigrationinhibition
AT caoyutao apolydopaminecoatedplatinumnanoplatformfortumortargetedphotothermalablationandmigrationinhibition
AT sunxiao apolydopaminecoatedplatinumnanoplatformfortumortargetedphotothermalablationandmigrationinhibition
AT wanghaijun apolydopaminecoatedplatinumnanoplatformfortumortargetedphotothermalablationandmigrationinhibition
AT dongjian apolydopaminecoatedplatinumnanoplatformfortumortargetedphotothermalablationandmigrationinhibition
AT zouxianwen polydopaminecoatedplatinumnanoplatformfortumortargetedphotothermalablationandmigrationinhibition
AT maguiqi polydopaminecoatedplatinumnanoplatformfortumortargetedphotothermalablationandmigrationinhibition
AT zhupengyu polydopaminecoatedplatinumnanoplatformfortumortargetedphotothermalablationandmigrationinhibition
AT caoyutao polydopaminecoatedplatinumnanoplatformfortumortargetedphotothermalablationandmigrationinhibition
AT sunxiao polydopaminecoatedplatinumnanoplatformfortumortargetedphotothermalablationandmigrationinhibition
AT wanghaijun polydopaminecoatedplatinumnanoplatformfortumortargetedphotothermalablationandmigrationinhibition
AT dongjian polydopaminecoatedplatinumnanoplatformfortumortargetedphotothermalablationandmigrationinhibition