Identification of cell type specific ACE2 modifiers by CRISPR screening

SARS-CoV-2 infection is initiated by binding of the viral spike protein to its receptor, ACE2, on the surface of host cells. ACE2 expression is heterogeneous both in vivo and in immortalized cell lines, but the molecular pathways that govern ACE2 expression remain unclear. We now report high-through...

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Detalles Bibliográficos
Autores principales: Sherman, Emily J., Mirabelli, Carmen, Tang, Vi T., Khan, Taslima G., Leix, Kyle, Kennedy, Andrew A., Graham, Sarah E., Willer, Cristen J., Tai, Andrew W., Sexton, Jonathan Z., Wobus, Christiane E., Emmer, Brian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929698/
https://www.ncbi.nlm.nih.gov/pubmed/35231079
http://dx.doi.org/10.1371/journal.ppat.1010377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929698/
https://www.ncbi.nlm.nih.gov/pubmed/35231079
http://dx.doi.org/10.1371/journal.ppat.1010377

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