Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns

SARS-CoV-2 attaches to angiotensin-converting enzyme 2 (ACE2) to gain entry into cells after which the spike protein is cleaved by the transmembrane serine protease 2 (TMPRSS2) to facilitate viral-host membrane fusion. ACE2 and TMPRSS2 expression profiles have been analyzed at the genomic, transcrip...

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Detalles Bibliográficos
Autores principales: Tomris, Ilhan, Bouwman, Kim M., Adolfs, Youri, Noack, Danny, van der Woude, Roosmarijn, Kerster, Gius, Herfst, Sander, Sanders, Rogier W., van Gils, Marit J., Boons, Geert-Jan, Haagmans, Bart L., Pasterkamp, R. Jeroen, Rockx, Barry, de Vries, Robert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930000/
https://www.ncbi.nlm.nih.gov/pubmed/35255100
http://dx.doi.org/10.1371/journal.ppat.1010340

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