Cargando…

Cis-epistasis at the LPA locus and risk of cardiovascular diseases

AIMS: Coronary artery disease (CAD) has a strong genetic predisposition. However, despite substantial discoveries made by genome-wide association studies (GWAS), a large proportion of heritability awaits identification. Non-additive genetic effects might be responsible for part of the unaccounted ge...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Lingyao, Moser, Sylvain, Mirza-Schreiber, Nazanin, Lamina, Claudia, Coassin, Stefan, Nelson, Christopher P, Annilo, Tarmo, Franzén, Oscar, Kleber, Marcus E, Mack, Salome, Andlauer, Till F M, Jiang, Beibei, Stiller, Barbara, Li, Ling, Willenborg, Christina, Munz, Matthias, Kessler, Thorsten, Kastrati, Adnan, Laugwitz, Karl-Ludwig, Erdmann, Jeanette, Moebus, Susanne, Nöthen, Markus M, Peters, Annette, Strauch, Konstantin, Müller-Nurasyid, Martina, Gieger, Christian, Meitinger, Thomas, Steinhagen-Thiessen, Elisabeth, März, Winfried, Metspalu, Andres, Björkegren, Johan L M, Samani, Nilesh J, Kronenberg, Florian, Müller-Myhsok, Bertram, Schunkert, Heribert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930071/ https://www.ncbi.nlm.nih.gov/pubmed/33878186 http://dx.doi.org/10.1093/cvr/cvab136

Ejemplares similares

The effect of LPA Thr3888Pro on lipoprotein(a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G>A
por: Grüneis, Rebecca, et al.
Publicado: (2022)

The kringle IV type 2 domain variant 4925G>A causes the elusive association signal of the LPA pentanucleotide repeat
por: Grüneis, Rebecca, et al.
Publicado: (2022)

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter
por: Coassin, Stefan, et al.
Publicado: (2020)

Lipoprotein(a) beyond the kringle IV repeat polymorphism: The complexity of genetic variation in the LPA gene
por: Coassin, Stefan, et al.
Publicado: (2022)

A comprehensive map of single-base polymorphisms in the hypervariable LPA kringle IV type 2 copy number variation region
por: Coassin, Stefan, et al.
Publicado: (2019)

Prevalence of obesity in primary care using different anthropometric measures – Results of the German Metabolic and Cardiovascular Risk Project (GEMCAS)
por: Hauner, Hans, et al.
Publicado: (2008)

Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease
por: Schachtl-Riess, Johanna F., et al.
Publicado: (2021)

A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction
por: Coassin, Stefan, et al.
Publicado: (2017)

Dyslipidemia in primary care – prevalence, recognition, treatment and control: data from the German Metabolic and Cardiovascular Risk Project (GEMCAS)
por: Steinhagen-Thiessen, Elisabeth, et al.
Publicado: (2008)

LPA(1), LPA(2), LPA(4), and LPA(6) receptor expression during mouse brain development
por: Suckau, Olga, et al.
Publicado: (2019)

MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene (NR3C2) expression
por: Sõber, Siim, et al.
Publicado: (2010)

Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression
por: Annilo, Tarmo, et al.
Publicado: (2009)

A Systematic Evaluation of Short Tandem Repeats in Lipid Candidate Genes: Riding on the SNP-Wave
por: Lamina, Claudia, et al.
Publicado: (2014)

Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA(1), LPA(2), and LPA(3)
por: Alcántara-Hernández, Rocío, et al.
Publicado: (2015)

Mental Health and Psychosocial Functioning Over the Lifespan of German Patients Undergoing Cardiac Catheterization for Coronary Artery Disease
por: Schaich, Anja, et al.
Publicado: (2018)

Regulation of T Cell Motility In Vitro and In Vivo by LPA and LPA2
por: Knowlden, Sara A., et al.
Publicado: (2014)

Altered Gene Expression Associated with microRNA Binding Site Polymorphisms
por: Võsa, Urmo, et al.
Publicado: (2015)

A human-specific VNTR in the TRIB3 promoter causes gene expression variation between individuals
por: Örd, Tiit, et al.
Publicado: (2020)

Association of Genetic Variation at AQP4 Locus with Vascular Depression
por: Westermair, Anna L., et al.
Publicado: (2018)

Effect of Erythropoietin in patients with acute myocardial infarction: five-year results of the REVIVAL-3 trial
por: Steppich, Birgit, et al.
Publicado: (2017)

Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA(1) Pathway
por: Dario, Moreno-Fernández Román, et al.
Publicado: (2018)

Effects of the LPA(1) Receptor Deficiency and Stress on the Hippocampal LPA Species in Mice
por: Tabbai, Sara, et al.
Publicado: (2019)

Genetic Factors Explain a Major Fraction of the 50% Lower Lipoprotein(a) Concentrations in Finns
por: Erhart, Gertraud, et al.
Publicado: (2018)

An LPA species (18:1 LPA) plays key roles in the self-amplification of spinal LPA production in the peripheral neuropathic pain model
por: Ma, Lin, et al.
Publicado: (2013)

Time-of-day at symptom onset was not associated with infarct size and long-term prognosis in patients with ST-segment elevation myocardial infarction
por: Sager, Hendrik B., et al.
Publicado: (2019)

Mutation analysis and copy number alterations of KIF23 in non-small-cell lung cancer exhibiting KIF23 over-expression
por: Vikberg, Ann-Louise, et al.
Publicado: (2017)

LPA receptor 1 mediates LPA-induced ovarian cancer metastasis: an in vitro and in vivo study
por: Yu, Xuechen, et al.
Publicado: (2016)

Phosphatidic Acid Stimulates Myoblast Proliferation through Interaction with LPA1 and LPA2 Receptors
por: Gomez-Larrauri, Ana, et al.
Publicado: (2021)

LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis
por: Windischhofer, Werner, et al.
Publicado: (2012)

Methylation Markers of Early-Stage Non-Small Cell Lung Cancer
por: Lokk, Kaie, et al.
Publicado: (2012)

Correction: Methylation Markers of Early-Stage Non-Small Cell Lung Cancer
por: Lokk, Kaie, et al.
Publicado: (2017)

Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk
por: Brænne, Ingrid, et al.
Publicado: (2017)

Genetic and modifiable risk factors combine multiplicatively in common disease
por: Pang, Shichao, et al.
Publicado: (2022)

LPA Scheme for the LHC Luminosity Upgrade
por: Bhat, C
Publicado: (2009)

Lysophosphatidic acid and its receptors LPA(1) and LPA(3) mediate paclitaxel-induced neuropathic pain in mice
por: Uchida, Hitoshi, et al.
Publicado: (2014)

Metagenes Associated with Survival in Non-Small Cell Lung Cancer
por: Urgard, Egon, et al.
Publicado: (2011)

Is High-Density Lipoprotein Cholesterol Causally Related to Kidney Function?: Evidence From Genetic Epidemiological Studies
por: Coassin, Stefan, et al.
Publicado: (2016)

Evaluating the Causal Relation of ApoA-IV with Disease-Related Traits - A Bidirectional Two-sample Mendelian Randomization Study
por: Mack, Salome, et al.
Publicado: (2017)

C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis
por: Lepik, Kaido, et al.
Publicado: (2017)

LPA Is a Chemorepellent for B16 Melanoma Cells: Action through the cAMP-Elevating LPA(5) Receptor
por: Jongsma, Maikel, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_2tghip7l4i5oqgaati7sljqc4v