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Reinfection with SARS-CoV-2: An inconvenient truth?

Data show that antibody-related immunity against SARS-CoV-2 may not be long-lasting. We report two cases regarded as cured from COVID-19, which presented again with symptoms and a positive SARS-CoV-2 RT-PCR test. Case one, a 60-year-old male, had a biphasic presentation of symptoms compatible with C...

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Autores principales: Sonié, Pedro, Manuel-Silva, Jorge, Rafael, Alexandra, Amorim-Alves, Luís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930163/
https://www.ncbi.nlm.nih.gov/pubmed/35309639
http://dx.doi.org/10.4103/jfmpc.jfmpc_1490_21
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author Sonié, Pedro
Manuel-Silva, Jorge
Rafael, Alexandra
Amorim-Alves, Luís
author_facet Sonié, Pedro
Manuel-Silva, Jorge
Rafael, Alexandra
Amorim-Alves, Luís
author_sort Sonié, Pedro
collection PubMed
description Data show that antibody-related immunity against SARS-CoV-2 may not be long-lasting. We report two cases regarded as cured from COVID-19, which presented again with symptoms and a positive SARS-CoV-2 RT-PCR test. Case one, a 60-year-old male, had a biphasic presentation of symptoms compatible with COVID-19 infection, associated with a positive RT-PCR test. Case two, a 25-year-old female, had a first positive RT-PCR test during hospital screening, and months later a symptomatic presentation of COVID-19, associated with a positive RT-PCR test. All cases were immunocompetent. Anti-IgG-SARS-CoV-2 blood samples were negative in both. Elevation of analytical inflammatory markers suggested new infection in both cases. COVID-19 reinfection may be a differential diagnosis and primary care physicians should acknowledge it. Previously cured patients should be encouraged to comply with health public preventive measures.
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spelling pubmed-89301632022-03-18 Reinfection with SARS-CoV-2: An inconvenient truth? Sonié, Pedro Manuel-Silva, Jorge Rafael, Alexandra Amorim-Alves, Luís J Family Med Prim Care Case Report Data show that antibody-related immunity against SARS-CoV-2 may not be long-lasting. We report two cases regarded as cured from COVID-19, which presented again with symptoms and a positive SARS-CoV-2 RT-PCR test. Case one, a 60-year-old male, had a biphasic presentation of symptoms compatible with COVID-19 infection, associated with a positive RT-PCR test. Case two, a 25-year-old female, had a first positive RT-PCR test during hospital screening, and months later a symptomatic presentation of COVID-19, associated with a positive RT-PCR test. All cases were immunocompetent. Anti-IgG-SARS-CoV-2 blood samples were negative in both. Elevation of analytical inflammatory markers suggested new infection in both cases. COVID-19 reinfection may be a differential diagnosis and primary care physicians should acknowledge it. Previously cured patients should be encouraged to comply with health public preventive measures. Wolters Kluwer - Medknow 2022-01 2022-01-31 /pmc/articles/PMC8930163/ /pubmed/35309639 http://dx.doi.org/10.4103/jfmpc.jfmpc_1490_21 Text en Copyright: © 2022 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Sonié, Pedro
Manuel-Silva, Jorge
Rafael, Alexandra
Amorim-Alves, Luís
Reinfection with SARS-CoV-2: An inconvenient truth?
title Reinfection with SARS-CoV-2: An inconvenient truth?
title_full Reinfection with SARS-CoV-2: An inconvenient truth?
title_fullStr Reinfection with SARS-CoV-2: An inconvenient truth?
title_full_unstemmed Reinfection with SARS-CoV-2: An inconvenient truth?
title_short Reinfection with SARS-CoV-2: An inconvenient truth?
title_sort reinfection with sars-cov-2: an inconvenient truth?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930163/
https://www.ncbi.nlm.nih.gov/pubmed/35309639
http://dx.doi.org/10.4103/jfmpc.jfmpc_1490_21
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