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Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants

Virus-like particle (VLP) and live virus assays were used to investigate neutralizing immunity against Delta and Omicron SARS-CoV-2 variants in 259 samples from 128 vaccinated individuals. Following Delta breakthrough infection, titers against WT rose 57-fold and 3.1-fold compared with uninfected bo...

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Autores principales: Servellita, Venice, Syed, Abdullah M., Morris, Mary Kate, Brazer, Noah, Saldhi, Prachi, Garcia-Knight, Miguel, Sreekumar, Bharath, Khalid, Mir M., Ciling, Alison, Chen, Pei-Yi, Kumar, G. Renuka, Gliwa, Amelia S., Nguyen, Jenny, Sotomayor-Gonzalez, Alicia, Zhang, Yueyuan, Frias, Edwin, Prostko, John, Hackett, John, Andino, Raul, Wadford, Debra A., Hanson, Carl, Doudna, Jennifer, Ott, Melanie, Chiu, Charles Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930394/
https://www.ncbi.nlm.nih.gov/pubmed/35429436
http://dx.doi.org/10.1016/j.cell.2022.03.019
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author Servellita, Venice
Syed, Abdullah M.
Morris, Mary Kate
Brazer, Noah
Saldhi, Prachi
Garcia-Knight, Miguel
Sreekumar, Bharath
Khalid, Mir M.
Ciling, Alison
Chen, Pei-Yi
Kumar, G. Renuka
Gliwa, Amelia S.
Nguyen, Jenny
Sotomayor-Gonzalez, Alicia
Zhang, Yueyuan
Frias, Edwin
Prostko, John
Hackett, John
Andino, Raul
Wadford, Debra A.
Hanson, Carl
Doudna, Jennifer
Ott, Melanie
Chiu, Charles Y.
author_facet Servellita, Venice
Syed, Abdullah M.
Morris, Mary Kate
Brazer, Noah
Saldhi, Prachi
Garcia-Knight, Miguel
Sreekumar, Bharath
Khalid, Mir M.
Ciling, Alison
Chen, Pei-Yi
Kumar, G. Renuka
Gliwa, Amelia S.
Nguyen, Jenny
Sotomayor-Gonzalez, Alicia
Zhang, Yueyuan
Frias, Edwin
Prostko, John
Hackett, John
Andino, Raul
Wadford, Debra A.
Hanson, Carl
Doudna, Jennifer
Ott, Melanie
Chiu, Charles Y.
author_sort Servellita, Venice
collection PubMed
description Virus-like particle (VLP) and live virus assays were used to investigate neutralizing immunity against Delta and Omicron SARS-CoV-2 variants in 259 samples from 128 vaccinated individuals. Following Delta breakthrough infection, titers against WT rose 57-fold and 3.1-fold compared with uninfected boosted and unboosted individuals, respectively, versus only a 5.8-fold increase and 3.1-fold decrease for Omicron breakthrough infection. Among immunocompetent, unboosted patients, Delta breakthrough infections induced 10.8-fold higher titers against WT compared with Omicron (p = 0.037). Decreased antibody responses in Omicron breakthrough infections relative to Delta were potentially related to a higher proportion of asymptomatic or mild breakthrough infections (55.0% versus 28.6%, respectively), which exhibited 12.3-fold lower titers against WT compared with moderate to severe infections (p = 0.020). Following either Delta or Omicron breakthrough infection, limited variant-specific cross-neutralizing immunity was observed. These results suggest that Omicron breakthrough infections are less immunogenic than Delta, thus providing reduced protection against reinfection or infection from future variants.
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spelling pubmed-89303942022-03-18 Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants Servellita, Venice Syed, Abdullah M. Morris, Mary Kate Brazer, Noah Saldhi, Prachi Garcia-Knight, Miguel Sreekumar, Bharath Khalid, Mir M. Ciling, Alison Chen, Pei-Yi Kumar, G. Renuka Gliwa, Amelia S. Nguyen, Jenny Sotomayor-Gonzalez, Alicia Zhang, Yueyuan Frias, Edwin Prostko, John Hackett, John Andino, Raul Wadford, Debra A. Hanson, Carl Doudna, Jennifer Ott, Melanie Chiu, Charles Y. Cell Article Virus-like particle (VLP) and live virus assays were used to investigate neutralizing immunity against Delta and Omicron SARS-CoV-2 variants in 259 samples from 128 vaccinated individuals. Following Delta breakthrough infection, titers against WT rose 57-fold and 3.1-fold compared with uninfected boosted and unboosted individuals, respectively, versus only a 5.8-fold increase and 3.1-fold decrease for Omicron breakthrough infection. Among immunocompetent, unboosted patients, Delta breakthrough infections induced 10.8-fold higher titers against WT compared with Omicron (p = 0.037). Decreased antibody responses in Omicron breakthrough infections relative to Delta were potentially related to a higher proportion of asymptomatic or mild breakthrough infections (55.0% versus 28.6%, respectively), which exhibited 12.3-fold lower titers against WT compared with moderate to severe infections (p = 0.020). Following either Delta or Omicron breakthrough infection, limited variant-specific cross-neutralizing immunity was observed. These results suggest that Omicron breakthrough infections are less immunogenic than Delta, thus providing reduced protection against reinfection or infection from future variants. Elsevier Inc. 2022-04-28 2022-03-18 /pmc/articles/PMC8930394/ /pubmed/35429436 http://dx.doi.org/10.1016/j.cell.2022.03.019 Text en © 2022 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Servellita, Venice
Syed, Abdullah M.
Morris, Mary Kate
Brazer, Noah
Saldhi, Prachi
Garcia-Knight, Miguel
Sreekumar, Bharath
Khalid, Mir M.
Ciling, Alison
Chen, Pei-Yi
Kumar, G. Renuka
Gliwa, Amelia S.
Nguyen, Jenny
Sotomayor-Gonzalez, Alicia
Zhang, Yueyuan
Frias, Edwin
Prostko, John
Hackett, John
Andino, Raul
Wadford, Debra A.
Hanson, Carl
Doudna, Jennifer
Ott, Melanie
Chiu, Charles Y.
Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants
title Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants
title_full Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants
title_fullStr Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants
title_full_unstemmed Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants
title_short Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants
title_sort neutralizing immunity in vaccine breakthrough infections from the sars-cov-2 omicron and delta variants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930394/
https://www.ncbi.nlm.nih.gov/pubmed/35429436
http://dx.doi.org/10.1016/j.cell.2022.03.019
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