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Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders

In this Perspective review, we highlight some of the less explored aspects of lateral habenula (LHb) function in contextual memory, sleep, and behavioral flexibility. We provide evidence that LHb is well-situated to integrate different internal state and multimodal sensory information from memory-,...

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Autores principales: Baker, Phillip M., Mathis, Victor, Lecourtier, Lucas, Simmons, Sarah C., Nugent, Fereshteh S., Hill, Sierra, Mizumori, Sheri J. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930415/
https://www.ncbi.nlm.nih.gov/pubmed/35308564
http://dx.doi.org/10.3389/fnsys.2022.826475
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author Baker, Phillip M.
Mathis, Victor
Lecourtier, Lucas
Simmons, Sarah C.
Nugent, Fereshteh S.
Hill, Sierra
Mizumori, Sheri J. Y.
author_facet Baker, Phillip M.
Mathis, Victor
Lecourtier, Lucas
Simmons, Sarah C.
Nugent, Fereshteh S.
Hill, Sierra
Mizumori, Sheri J. Y.
author_sort Baker, Phillip M.
collection PubMed
description In this Perspective review, we highlight some of the less explored aspects of lateral habenula (LHb) function in contextual memory, sleep, and behavioral flexibility. We provide evidence that LHb is well-situated to integrate different internal state and multimodal sensory information from memory-, stress-, motivational-, and reward-related circuits essential for both survival and decision making. We further discuss the impact of early life stress (ELS) on LHb function as an example of stress-induced hyperactivity and dysregulation of neuromodulatory systems within the LHb that promote anhedonia and motivational deficits following ELS. We acknowledge that recent technological advancements in manipulation and recording of neural circuits in simplified and well-controlled behavioral paradigms have been invaluable in our understanding of the critical role of LHb in motivation and emotional regulation as well as the involvement of LHb dysfunction in stress-induced psychopathology. However, we also argue that the use of ethologically-relevant behaviors with consideration of complex aspects of decision-making is warranted for future studies of LHb contributions in a wide range of psychiatric illnesses. We conclude this Perspective with some of the outstanding issues for the field to consider where a multi-systems approach is needed to investigate the complex nature of LHb circuitry interactions with environmental stimuli that predisposes psychiatric disorders.
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spelling pubmed-89304152022-03-19 Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders Baker, Phillip M. Mathis, Victor Lecourtier, Lucas Simmons, Sarah C. Nugent, Fereshteh S. Hill, Sierra Mizumori, Sheri J. Y. Front Syst Neurosci Neuroscience In this Perspective review, we highlight some of the less explored aspects of lateral habenula (LHb) function in contextual memory, sleep, and behavioral flexibility. We provide evidence that LHb is well-situated to integrate different internal state and multimodal sensory information from memory-, stress-, motivational-, and reward-related circuits essential for both survival and decision making. We further discuss the impact of early life stress (ELS) on LHb function as an example of stress-induced hyperactivity and dysregulation of neuromodulatory systems within the LHb that promote anhedonia and motivational deficits following ELS. We acknowledge that recent technological advancements in manipulation and recording of neural circuits in simplified and well-controlled behavioral paradigms have been invaluable in our understanding of the critical role of LHb in motivation and emotional regulation as well as the involvement of LHb dysfunction in stress-induced psychopathology. However, we also argue that the use of ethologically-relevant behaviors with consideration of complex aspects of decision-making is warranted for future studies of LHb contributions in a wide range of psychiatric illnesses. We conclude this Perspective with some of the outstanding issues for the field to consider where a multi-systems approach is needed to investigate the complex nature of LHb circuitry interactions with environmental stimuli that predisposes psychiatric disorders. Frontiers Media S.A. 2022-03-03 /pmc/articles/PMC8930415/ /pubmed/35308564 http://dx.doi.org/10.3389/fnsys.2022.826475 Text en Copyright © 2022 Baker, Mathis, Lecourtier, Simmons, Nugent, Hill and Mizumori. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Baker, Phillip M.
Mathis, Victor
Lecourtier, Lucas
Simmons, Sarah C.
Nugent, Fereshteh S.
Hill, Sierra
Mizumori, Sheri J. Y.
Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders
title Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders
title_full Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders
title_fullStr Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders
title_full_unstemmed Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders
title_short Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders
title_sort lateral habenula beyond avoidance: roles in stress, memory, and decision-making with implications for psychiatric disorders
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930415/
https://www.ncbi.nlm.nih.gov/pubmed/35308564
http://dx.doi.org/10.3389/fnsys.2022.826475
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