Direct targeting of amplified gene loci for pro-apoptotic anticancer therapy

Gene amplification drives oncogenesis in a broad spectrum of cancers. A number of drugs have been developed to inhibit the protein products of amplified driver genes, but their clinical efficacy is often hampered by drug resistance. Here, we introduce a therapeutic strategy for targeting cancer-asso...

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Detalles Bibliográficos
Autores principales: Tiwari, Meetu Kaushik, Colon-Rios, Daniel A., Rao Tumu, Hemanta C, Liu, Yanfeng, Quijano, Elias, Krysztofiak, Adam, Chan, Cynthia, Song, Eric, Braddock, Demetrios T., Suh, Hee-Won, Mark Saltzman, W., Rogers, Faye A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930417/
https://www.ncbi.nlm.nih.gov/pubmed/34711990
http://dx.doi.org/10.1038/s41587-021-01057-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930417/
https://www.ncbi.nlm.nih.gov/pubmed/34711990
http://dx.doi.org/10.1038/s41587-021-01057-5

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