Engineered pegRNAs improve prime editing efficiency

Prime editing enables the installation of virtually any combination of point mutations, small insertions, or small deletions in the DNA of living cells. A prime editing guide RNA (pegRNA) directs the prime editor protein to the targeted locus and also encodes the desired edit. Here we demonstrate th...

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Detalles Bibliográficos
Autores principales: Nelson, James W., Randolph, Peyton B., Shen, Simon P., Everette, Kelcee A., Chen, Peter J., Anzalone, Andrew V., An, Meirui, Newby, Gregory A., Chen, Jonathan C., Hsu, Alvin, Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930418/
https://www.ncbi.nlm.nih.gov/pubmed/34608327
http://dx.doi.org/10.1038/s41587-021-01039-7

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