Neuroinflammation and Neuropathology

This review addresses the current understanding of the role of autoimmune neuroinflammation in the pathogenesis of vascular, neurodegenerative, and other diseases of the nervous system. The mechanisms of responses of resident CNS cells (glial cells, astrocytes) and peripheral immune system cells are...

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Autores principales: Esin, R. G., Safina, D. R., Khakimova, A. R., Esin, O. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930459/
https://www.ncbi.nlm.nih.gov/pubmed/35317271
http://dx.doi.org/10.1007/s11055-022-01223-5
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author Esin, R. G.
Safina, D. R.
Khakimova, A. R.
Esin, O. R.
author_facet Esin, R. G.
Safina, D. R.
Khakimova, A. R.
Esin, O. R.
author_sort Esin, R. G.
collection PubMed
description This review addresses the current understanding of the role of autoimmune neuroinflammation in the pathogenesis of vascular, neurodegenerative, and other diseases of the nervous system. The mechanisms of responses of resident CNS cells (glial cells, astrocytes) and peripheral immune system cells are presented. The therapeutic potentials of phosphodiesterase inhibitors, which have antiaggregant properties and can suppress autoimmune inflammation, are discussed. The phosphodiesterase inhibitor dipyridamole is regarded as a potential drug for this purpose.
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spelling pubmed-89304592022-03-18 Neuroinflammation and Neuropathology Esin, R. G. Safina, D. R. Khakimova, A. R. Esin, O. R. Neurosci Behav Physiol Article This review addresses the current understanding of the role of autoimmune neuroinflammation in the pathogenesis of vascular, neurodegenerative, and other diseases of the nervous system. The mechanisms of responses of resident CNS cells (glial cells, astrocytes) and peripheral immune system cells are presented. The therapeutic potentials of phosphodiesterase inhibitors, which have antiaggregant properties and can suppress autoimmune inflammation, are discussed. The phosphodiesterase inhibitor dipyridamole is regarded as a potential drug for this purpose. Springer International Publishing 2022-03-18 2022 /pmc/articles/PMC8930459/ /pubmed/35317271 http://dx.doi.org/10.1007/s11055-022-01223-5 Text en © Springer Nature Switzerland AG 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Esin, R. G.
Safina, D. R.
Khakimova, A. R.
Esin, O. R.
Neuroinflammation and Neuropathology
title Neuroinflammation and Neuropathology
title_full Neuroinflammation and Neuropathology
title_fullStr Neuroinflammation and Neuropathology
title_full_unstemmed Neuroinflammation and Neuropathology
title_short Neuroinflammation and Neuropathology
title_sort neuroinflammation and neuropathology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930459/
https://www.ncbi.nlm.nih.gov/pubmed/35317271
http://dx.doi.org/10.1007/s11055-022-01223-5
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