CIC-Mediated Modulation of MAPK Signaling Opposes Receptor Tyrosine Kinase Inhibitor Response in Kinase-Addicted Sarcoma

Kinase fusions have been identified in a growing subset of sarcomas, but a lack of preclinical models has impeded their functional analysis as therapeutic targets in the sarcoma setting. In this study, we generated models of sarcomas bearing kinase fusions and assessed their response to molecularly...

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Detalles Bibliográficos
Autores principales: Odintsov, Igor, Ortiz, Michael V., Khodos, Inna, Mattar, Marissa S., Lui, Allan J.W., Kohsaka, Shinji, de Stanchina, Elisa, Bender, Julia L. Glade, Ladanyi, Marc, Somwar, Romel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930606/
https://www.ncbi.nlm.nih.gov/pubmed/35074756
http://dx.doi.org/10.1158/0008-5472.CAN-21-1397

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