5-HTT genotype and inertia of negative affect in adolescents and young adults from the general population

The study aims to replicate the previous found association of 5-HTTLPR and inertia of negative affect in daily life of adolescents and young adults. Data of 877 adolescents (aged 14–21 years) of the Behavior and Mind Health (BeMIND) study (epidemiological cohort study, Dresden, Germany) were genotyp...

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Detalles Bibliográficos
Autores principales: Ollmann, T. M., Seidl, E., Venz, J., Pieper, L., Voss, C., Hoyer, J., Kische, H., Poppenhäger, S. R., Schiele, M. A., Domschke, K., Beesdo-Baum, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Psychiatry and Preclinical Psychiatric Studies - Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930868/
https://www.ncbi.nlm.nih.gov/pubmed/35246765
http://dx.doi.org/10.1007/s00702-022-02459-8
Descripción
Sumario:The study aims to replicate the previous found association of 5-HTTLPR and inertia of negative affect in daily life of adolescents and young adults. Data of 877 adolescents (aged 14–21 years) of the Behavior and Mind Health (BeMIND) study (epidemiological cohort study, Dresden, Germany) were genotyped for 5-HTTLPR/rs25531, grouped into SS/SL(G)/SL(A)/L(G)L(A)/L(G)L(G) vs. L(A)L(A), and provided ratings on negative affect items, depression and anxiety (Patient-Reported Outcomes Measurement Information System) eight times a day over 4 days. Multilevel regression models did not reveal an association of 5-HTTLPR genotype and inertia of negative affect, nor associations with inertia of anxiety or depression. Inertia of negative affect seems not to be a psychological mechanism through which 5-HTTLPR acts on psychopathology.

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