5-HTT genotype and inertia of negative affect in adolescents and young adults from the general population

The study aims to replicate the previous found association of 5-HTTLPR and inertia of negative affect in daily life of adolescents and young adults. Data of 877 adolescents (aged 14–21 years) of the Behavior and Mind Health (BeMIND) study (epidemiological cohort study, Dresden, Germany) were genotyp...

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Autores principales: Ollmann, T. M., Seidl, E., Venz, J., Pieper, L., Voss, C., Hoyer, J., Kische, H., Poppenhäger, S. R., Schiele, M. A., Domschke, K., Beesdo-Baum, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Psychiatry and Preclinical Psychiatric Studies - Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930868/
https://www.ncbi.nlm.nih.gov/pubmed/35246765
http://dx.doi.org/10.1007/s00702-022-02459-8
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author Ollmann, T. M.
Seidl, E.
Venz, J.
Pieper, L.
Voss, C.
Hoyer, J.
Kische, H.
Poppenhäger, S. R.
Schiele, M. A.
Domschke, K.
Beesdo-Baum, K.
author_facet Ollmann, T. M.
Seidl, E.
Venz, J.
Pieper, L.
Voss, C.
Hoyer, J.
Kische, H.
Poppenhäger, S. R.
Schiele, M. A.
Domschke, K.
Beesdo-Baum, K.
author_sort Ollmann, T. M.
collection PubMed
description The study aims to replicate the previous found association of 5-HTTLPR and inertia of negative affect in daily life of adolescents and young adults. Data of 877 adolescents (aged 14–21 years) of the Behavior and Mind Health (BeMIND) study (epidemiological cohort study, Dresden, Germany) were genotyped for 5-HTTLPR/rs25531, grouped into SS/SL(G)/SL(A)/L(G)L(A)/L(G)L(G) vs. L(A)L(A), and provided ratings on negative affect items, depression and anxiety (Patient-Reported Outcomes Measurement Information System) eight times a day over 4 days. Multilevel regression models did not reveal an association of 5-HTTLPR genotype and inertia of negative affect, nor associations with inertia of anxiety or depression. Inertia of negative affect seems not to be a psychological mechanism through which 5-HTTLPR acts on psychopathology.
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spelling pubmed-89308682022-04-07 5-HTT genotype and inertia of negative affect in adolescents and young adults from the general population Ollmann, T. M. Seidl, E. Venz, J. Pieper, L. Voss, C. Hoyer, J. Kische, H. Poppenhäger, S. R. Schiele, M. A. Domschke, K. Beesdo-Baum, K. J Neural Transm (Vienna) Psychiatry and Preclinical Psychiatric Studies - Original Article The study aims to replicate the previous found association of 5-HTTLPR and inertia of negative affect in daily life of adolescents and young adults. Data of 877 adolescents (aged 14–21 years) of the Behavior and Mind Health (BeMIND) study (epidemiological cohort study, Dresden, Germany) were genotyped for 5-HTTLPR/rs25531, grouped into SS/SL(G)/SL(A)/L(G)L(A)/L(G)L(G) vs. L(A)L(A), and provided ratings on negative affect items, depression and anxiety (Patient-Reported Outcomes Measurement Information System) eight times a day over 4 days. Multilevel regression models did not reveal an association of 5-HTTLPR genotype and inertia of negative affect, nor associations with inertia of anxiety or depression. Inertia of negative affect seems not to be a psychological mechanism through which 5-HTTLPR acts on psychopathology. Springer Vienna 2022-03-04 2022 /pmc/articles/PMC8930868/ /pubmed/35246765 http://dx.doi.org/10.1007/s00702-022-02459-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Psychiatry and Preclinical Psychiatric Studies - Original Article
Ollmann, T. M.
Seidl, E.
Venz, J.
Pieper, L.
Voss, C.
Hoyer, J.
Kische, H.
Poppenhäger, S. R.
Schiele, M. A.
Domschke, K.
Beesdo-Baum, K.
5-HTT genotype and inertia of negative affect in adolescents and young adults from the general population
title 5-HTT genotype and inertia of negative affect in adolescents and young adults from the general population
title_full 5-HTT genotype and inertia of negative affect in adolescents and young adults from the general population
title_fullStr 5-HTT genotype and inertia of negative affect in adolescents and young adults from the general population
title_full_unstemmed 5-HTT genotype and inertia of negative affect in adolescents and young adults from the general population
title_short 5-HTT genotype and inertia of negative affect in adolescents and young adults from the general population
title_sort 5-htt genotype and inertia of negative affect in adolescents and young adults from the general population
topic Psychiatry and Preclinical Psychiatric Studies - Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930868/
https://www.ncbi.nlm.nih.gov/pubmed/35246765
http://dx.doi.org/10.1007/s00702-022-02459-8
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