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An integrated TMS-EEG and MRI approach to explore the interregional connectivity of the default mode network
Explorations of the relation between brain anatomy and functional connections in the brain are crucial for shedding more light on network connectivity that sustains brain communication. In this study, by means of an integrative approach, we examined both the structural and functional connections of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930884/ https://www.ncbi.nlm.nih.gov/pubmed/35119502 http://dx.doi.org/10.1007/s00429-022-02453-6 |
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author | Esposito, Romina Bortoletto, Marta Zacà, Domenico Avesani, Paolo Miniussi, Carlo |
author_facet | Esposito, Romina Bortoletto, Marta Zacà, Domenico Avesani, Paolo Miniussi, Carlo |
author_sort | Esposito, Romina |
collection | PubMed |
description | Explorations of the relation between brain anatomy and functional connections in the brain are crucial for shedding more light on network connectivity that sustains brain communication. In this study, by means of an integrative approach, we examined both the structural and functional connections of the default mode network (DMN) in a group of sixteen healthy subjects. For each subject, the DMN was extracted from the structural and functional resonance imaging data; the areas that were part of the DMN were defined as the regions of interest. Then, the target network was structurally explored by diffusion-weighted imaging, tested by neurophysiological means, and retested by means of concurrent transcranial magnetic stimulation and electroencephalography (TMS-EEG). A series of correlational analyses were performed to explore the relationship between the amplitude of early-latency TMS-evoked potentials and the indexes of structural connectivity (weighted number of fibres and fractional anisotropy). Stimulation of the left or right parietal nodes of the DMN-induced activation in the contralateral parietal and frontocentral electrodes within 60 ms; this activation correlated with fractional anisotropy measures of the corpus callosum. These results showed that distant secondary activations after target stimulation can be predicted based on the target’s anatomical connections. Interestingly, structural features of the corpus callosum predicted the activation of the directly connected nodes, i.e., parietal-parietal nodes, and of the broader DMN network, i.e., parietal-frontal nodes, as identified with functional magnetic resonance imaging. Our results suggested that the proposed integrated approach would allow us to describe the contributory causal relationship between structural connectivity and functional connectivity of the DMN. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00429-022-02453-6. |
format | Online Article Text |
id | pubmed-8930884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-89308842022-04-01 An integrated TMS-EEG and MRI approach to explore the interregional connectivity of the default mode network Esposito, Romina Bortoletto, Marta Zacà, Domenico Avesani, Paolo Miniussi, Carlo Brain Struct Funct Original Article Explorations of the relation between brain anatomy and functional connections in the brain are crucial for shedding more light on network connectivity that sustains brain communication. In this study, by means of an integrative approach, we examined both the structural and functional connections of the default mode network (DMN) in a group of sixteen healthy subjects. For each subject, the DMN was extracted from the structural and functional resonance imaging data; the areas that were part of the DMN were defined as the regions of interest. Then, the target network was structurally explored by diffusion-weighted imaging, tested by neurophysiological means, and retested by means of concurrent transcranial magnetic stimulation and electroencephalography (TMS-EEG). A series of correlational analyses were performed to explore the relationship between the amplitude of early-latency TMS-evoked potentials and the indexes of structural connectivity (weighted number of fibres and fractional anisotropy). Stimulation of the left or right parietal nodes of the DMN-induced activation in the contralateral parietal and frontocentral electrodes within 60 ms; this activation correlated with fractional anisotropy measures of the corpus callosum. These results showed that distant secondary activations after target stimulation can be predicted based on the target’s anatomical connections. Interestingly, structural features of the corpus callosum predicted the activation of the directly connected nodes, i.e., parietal-parietal nodes, and of the broader DMN network, i.e., parietal-frontal nodes, as identified with functional magnetic resonance imaging. Our results suggested that the proposed integrated approach would allow us to describe the contributory causal relationship between structural connectivity and functional connectivity of the DMN. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00429-022-02453-6. Springer Berlin Heidelberg 2022-02-04 2022 /pmc/articles/PMC8930884/ /pubmed/35119502 http://dx.doi.org/10.1007/s00429-022-02453-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Esposito, Romina Bortoletto, Marta Zacà, Domenico Avesani, Paolo Miniussi, Carlo An integrated TMS-EEG and MRI approach to explore the interregional connectivity of the default mode network |
title | An integrated TMS-EEG and MRI approach to explore the interregional connectivity of the default mode network |
title_full | An integrated TMS-EEG and MRI approach to explore the interregional connectivity of the default mode network |
title_fullStr | An integrated TMS-EEG and MRI approach to explore the interregional connectivity of the default mode network |
title_full_unstemmed | An integrated TMS-EEG and MRI approach to explore the interregional connectivity of the default mode network |
title_short | An integrated TMS-EEG and MRI approach to explore the interregional connectivity of the default mode network |
title_sort | integrated tms-eeg and mri approach to explore the interregional connectivity of the default mode network |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930884/ https://www.ncbi.nlm.nih.gov/pubmed/35119502 http://dx.doi.org/10.1007/s00429-022-02453-6 |
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