Cargando…

Inflammation/Coagulopathy/Immunology Responsive Index Predicts Poor COVID-19 Prognosis

In the early stage of coronavirus disease 2019 (COVID-19), most cases are identified as mild or moderate illnesses. Approximately 20% of hospitalised patients become severe or critical at the middle or late stage of the disease. The predictors and risk factors for prognosis in those with mild or mod...

Descripción completa

Detalles Bibliográficos
Autores principales: An, Hui, Zhang, Jitai, Li, Ting, Hu, Yuxin, Wang, Qian, Chen, Chengshui, Ying, Binyu, Jin, Shengwei, Li, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930906/
https://www.ncbi.nlm.nih.gov/pubmed/35310845
http://dx.doi.org/10.3389/fcimb.2022.807332
_version_ 1784671138160312320
author An, Hui
Zhang, Jitai
Li, Ting
Hu, Yuxin
Wang, Qian
Chen, Chengshui
Ying, Binyu
Jin, Shengwei
Li, Ming
author_facet An, Hui
Zhang, Jitai
Li, Ting
Hu, Yuxin
Wang, Qian
Chen, Chengshui
Ying, Binyu
Jin, Shengwei
Li, Ming
author_sort An, Hui
collection PubMed
description In the early stage of coronavirus disease 2019 (COVID-19), most cases are identified as mild or moderate illnesses. Approximately 20% of hospitalised patients become severe or critical at the middle or late stage of the disease. The predictors and risk factors for prognosis in those with mild or moderate disease remain to be determined. Of 694 patients with COVID-19, 231 patients with mild or moderate disease, who were hospitalised at 10 hospitals in Wenzhou and nearby counties in China, were enrolled in this retrospective study from 17 January to 20 March 2020. The outcomes of these patients included progression from mild/moderate illness to severe or critical conditions. Among the 231 patients, 49 (21.2%) had a poor prognosis in the hospital. Multivariate logistic regression analysis showed that higher inflammation/coagulopathy/immunology responsive index (ICIRI=[c-reactive protein × fibrinogen × D-dimer]/CD8 T cell count) on admission (OR=345.151, 95% CI=23.014−5176.318) was associated with increased odds ratios for poor prognosis. The area under the receiver operating characteristic curve for ICIRI predicting severe and critical condition progression was 0.65 (95% CI=0.519−0.782) and 0.80 (95% CI=0.647−0.954), with cut-off values of 870.83 and 535.44, respectively. Conversely, age, sex, comorbidity, neutrophil/lymphocyte ratio, CD8 T cell count, and c-reactive protein, fibrinogen, and D-dimer levels alone at admission were not good predictors of poor prognosis in patients with mild or moderate COVID-19. At admission, a novel index, ICIRI, tends to be the most promising predictor of COVID-19 progression from mild or moderate illness to severe or critical conditions.
format Online
Article
Text
id pubmed-8930906
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89309062022-03-19 Inflammation/Coagulopathy/Immunology Responsive Index Predicts Poor COVID-19 Prognosis An, Hui Zhang, Jitai Li, Ting Hu, Yuxin Wang, Qian Chen, Chengshui Ying, Binyu Jin, Shengwei Li, Ming Front Cell Infect Microbiol Cellular and Infection Microbiology In the early stage of coronavirus disease 2019 (COVID-19), most cases are identified as mild or moderate illnesses. Approximately 20% of hospitalised patients become severe or critical at the middle or late stage of the disease. The predictors and risk factors for prognosis in those with mild or moderate disease remain to be determined. Of 694 patients with COVID-19, 231 patients with mild or moderate disease, who were hospitalised at 10 hospitals in Wenzhou and nearby counties in China, were enrolled in this retrospective study from 17 January to 20 March 2020. The outcomes of these patients included progression from mild/moderate illness to severe or critical conditions. Among the 231 patients, 49 (21.2%) had a poor prognosis in the hospital. Multivariate logistic regression analysis showed that higher inflammation/coagulopathy/immunology responsive index (ICIRI=[c-reactive protein × fibrinogen × D-dimer]/CD8 T cell count) on admission (OR=345.151, 95% CI=23.014−5176.318) was associated with increased odds ratios for poor prognosis. The area under the receiver operating characteristic curve for ICIRI predicting severe and critical condition progression was 0.65 (95% CI=0.519−0.782) and 0.80 (95% CI=0.647−0.954), with cut-off values of 870.83 and 535.44, respectively. Conversely, age, sex, comorbidity, neutrophil/lymphocyte ratio, CD8 T cell count, and c-reactive protein, fibrinogen, and D-dimer levels alone at admission were not good predictors of poor prognosis in patients with mild or moderate COVID-19. At admission, a novel index, ICIRI, tends to be the most promising predictor of COVID-19 progression from mild or moderate illness to severe or critical conditions. Frontiers Media S.A. 2022-03-04 /pmc/articles/PMC8930906/ /pubmed/35310845 http://dx.doi.org/10.3389/fcimb.2022.807332 Text en Copyright © 2022 An, Zhang, Li, Hu, Wang, Chen, Ying, Jin and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
An, Hui
Zhang, Jitai
Li, Ting
Hu, Yuxin
Wang, Qian
Chen, Chengshui
Ying, Binyu
Jin, Shengwei
Li, Ming
Inflammation/Coagulopathy/Immunology Responsive Index Predicts Poor COVID-19 Prognosis
title Inflammation/Coagulopathy/Immunology Responsive Index Predicts Poor COVID-19 Prognosis
title_full Inflammation/Coagulopathy/Immunology Responsive Index Predicts Poor COVID-19 Prognosis
title_fullStr Inflammation/Coagulopathy/Immunology Responsive Index Predicts Poor COVID-19 Prognosis
title_full_unstemmed Inflammation/Coagulopathy/Immunology Responsive Index Predicts Poor COVID-19 Prognosis
title_short Inflammation/Coagulopathy/Immunology Responsive Index Predicts Poor COVID-19 Prognosis
title_sort inflammation/coagulopathy/immunology responsive index predicts poor covid-19 prognosis
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930906/
https://www.ncbi.nlm.nih.gov/pubmed/35310845
http://dx.doi.org/10.3389/fcimb.2022.807332
work_keys_str_mv AT anhui inflammationcoagulopathyimmunologyresponsiveindexpredictspoorcovid19prognosis
AT zhangjitai inflammationcoagulopathyimmunologyresponsiveindexpredictspoorcovid19prognosis
AT liting inflammationcoagulopathyimmunologyresponsiveindexpredictspoorcovid19prognosis
AT huyuxin inflammationcoagulopathyimmunologyresponsiveindexpredictspoorcovid19prognosis
AT wangqian inflammationcoagulopathyimmunologyresponsiveindexpredictspoorcovid19prognosis
AT chenchengshui inflammationcoagulopathyimmunologyresponsiveindexpredictspoorcovid19prognosis
AT yingbinyu inflammationcoagulopathyimmunologyresponsiveindexpredictspoorcovid19prognosis
AT jinshengwei inflammationcoagulopathyimmunologyresponsiveindexpredictspoorcovid19prognosis
AT liming inflammationcoagulopathyimmunologyresponsiveindexpredictspoorcovid19prognosis