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Meniscus position and size in knees with versus without structural knee osteoarthritis progression: data from the osteoarthritis initiative
OBJECTIVE: To explore whether and which quantitative 3D measures of medial and/or lateral meniscus position and size are associated with subsequent medial femorotibial structural progression of knee osteoarthritis and to determine the correlation between central slice and total meniscus measures. MA...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930934/ https://www.ncbi.nlm.nih.gov/pubmed/34591163 http://dx.doi.org/10.1007/s00256-021-03911-8 |
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author | Sharma, Kalpana Eckstein, Felix Wirth, Wolfgang Emmanuel, Katja |
author_facet | Sharma, Kalpana Eckstein, Felix Wirth, Wolfgang Emmanuel, Katja |
author_sort | Sharma, Kalpana |
collection | PubMed |
description | OBJECTIVE: To explore whether and which quantitative 3D measures of medial and/or lateral meniscus position and size are associated with subsequent medial femorotibial structural progression of knee osteoarthritis and to determine the correlation between central slice and total meniscus measures. MATERIALS AND METHODS: Knees with radiographic osteoarthritis from Osteoarthritis Initiative participants with longitudinal medial MRI-based cartilage thickness and radiographic joint space width (JSW) loss over 12 months were selected. These 37 structural progressor knees (64.7 ± 8.0y, 30.2 ± 4.6 kg/m(2), 35% men) were matched 1:1 to 37 non-progressor knees (64.6 ± 9.8y, 30.2 ± 4.4 kg/m(2), 35% men) without cartilage thickness or JSW loss. Quantitative measures of meniscus position and size were computed from manual segmentations of coronal baseline MRIs. Cohen’s D was used as measure of effect size. RESULTS: Maximum extrusion distance of the total medial meniscus and mean extrusion in the central 5 and in the central slice were greater for progressor than non-progressor knees (Cohen’s D 0.58–0.66). No significant differences were observed for medial tibial coverage or mean extrusion (entire meniscus). Among medial meniscus morphology measures, only mean height differed between progressor vs non-progressor knees (Cohen’s D 0.40). Among lateral meniscus measures, height and volume were greater in progressor vs. non-progressor knees (Cohen’s D 0.46–0.83). Mean extrusion measures were highly correlated between the entire meniscus and the central (r = 0.88) or the central 5 (r = 0.93) slices. CONCLUSIONS: 3D maximum and central medial meniscus extrusion may serve as predictors for subsequent structural progression. Central meniscus extrusion measures could substitute 3D extrusion measurement across the entire meniscus. |
format | Online Article Text |
id | pubmed-8930934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-89309342022-04-01 Meniscus position and size in knees with versus without structural knee osteoarthritis progression: data from the osteoarthritis initiative Sharma, Kalpana Eckstein, Felix Wirth, Wolfgang Emmanuel, Katja Skeletal Radiol Scientific Article OBJECTIVE: To explore whether and which quantitative 3D measures of medial and/or lateral meniscus position and size are associated with subsequent medial femorotibial structural progression of knee osteoarthritis and to determine the correlation between central slice and total meniscus measures. MATERIALS AND METHODS: Knees with radiographic osteoarthritis from Osteoarthritis Initiative participants with longitudinal medial MRI-based cartilage thickness and radiographic joint space width (JSW) loss over 12 months were selected. These 37 structural progressor knees (64.7 ± 8.0y, 30.2 ± 4.6 kg/m(2), 35% men) were matched 1:1 to 37 non-progressor knees (64.6 ± 9.8y, 30.2 ± 4.4 kg/m(2), 35% men) without cartilage thickness or JSW loss. Quantitative measures of meniscus position and size were computed from manual segmentations of coronal baseline MRIs. Cohen’s D was used as measure of effect size. RESULTS: Maximum extrusion distance of the total medial meniscus and mean extrusion in the central 5 and in the central slice were greater for progressor than non-progressor knees (Cohen’s D 0.58–0.66). No significant differences were observed for medial tibial coverage or mean extrusion (entire meniscus). Among medial meniscus morphology measures, only mean height differed between progressor vs non-progressor knees (Cohen’s D 0.40). Among lateral meniscus measures, height and volume were greater in progressor vs. non-progressor knees (Cohen’s D 0.46–0.83). Mean extrusion measures were highly correlated between the entire meniscus and the central (r = 0.88) or the central 5 (r = 0.93) slices. CONCLUSIONS: 3D maximum and central medial meniscus extrusion may serve as predictors for subsequent structural progression. Central meniscus extrusion measures could substitute 3D extrusion measurement across the entire meniscus. Springer Berlin Heidelberg 2021-09-30 2022 /pmc/articles/PMC8930934/ /pubmed/34591163 http://dx.doi.org/10.1007/s00256-021-03911-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Scientific Article Sharma, Kalpana Eckstein, Felix Wirth, Wolfgang Emmanuel, Katja Meniscus position and size in knees with versus without structural knee osteoarthritis progression: data from the osteoarthritis initiative |
title | Meniscus position and size in knees with versus without structural knee osteoarthritis progression: data from the osteoarthritis initiative |
title_full | Meniscus position and size in knees with versus without structural knee osteoarthritis progression: data from the osteoarthritis initiative |
title_fullStr | Meniscus position and size in knees with versus without structural knee osteoarthritis progression: data from the osteoarthritis initiative |
title_full_unstemmed | Meniscus position and size in knees with versus without structural knee osteoarthritis progression: data from the osteoarthritis initiative |
title_short | Meniscus position and size in knees with versus without structural knee osteoarthritis progression: data from the osteoarthritis initiative |
title_sort | meniscus position and size in knees with versus without structural knee osteoarthritis progression: data from the osteoarthritis initiative |
topic | Scientific Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930934/ https://www.ncbi.nlm.nih.gov/pubmed/34591163 http://dx.doi.org/10.1007/s00256-021-03911-8 |
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