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Motor sequences; separating the sequence from the motor. A longitudinal rsfMRI study
In motor learning, sequence specificity, i.e. the learning of specific sequential associations, has predominantly been studied using task-based fMRI paradigms. However, offline changes in resting state functional connectivity after sequence-specific motor learning are less well understood. Previous...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930963/ https://www.ncbi.nlm.nih.gov/pubmed/34704176 http://dx.doi.org/10.1007/s00429-021-02412-7 |
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author | Jäger, Anna-Thekla P. Huntenburg, Julia M. Tremblay, Stefanie A. Schneider, Uta Grahl, Sophia Huck, Julia Tardif, Christine L. Villringer, Arno Gauthier, Claudine J. Bazin, Pierre-Louis Steele, Christopher J. |
author_facet | Jäger, Anna-Thekla P. Huntenburg, Julia M. Tremblay, Stefanie A. Schneider, Uta Grahl, Sophia Huck, Julia Tardif, Christine L. Villringer, Arno Gauthier, Claudine J. Bazin, Pierre-Louis Steele, Christopher J. |
author_sort | Jäger, Anna-Thekla P. |
collection | PubMed |
description | In motor learning, sequence specificity, i.e. the learning of specific sequential associations, has predominantly been studied using task-based fMRI paradigms. However, offline changes in resting state functional connectivity after sequence-specific motor learning are less well understood. Previous research has established that plastic changes following motor learning can be divided into stages including fast learning, slow learning and retention. A description of how resting state functional connectivity after sequence-specific motor sequence learning (MSL) develops across these stages is missing. This study aimed to identify plastic alterations in whole-brain functional connectivity after learning a complex motor sequence by contrasting an active group who learned a complex sequence with a control group who performed a control task matched for motor execution. Resting state fMRI and behavioural performance were collected in both groups over the course of 5 consecutive training days and at follow-up after 12 days to encompass fast learning, slow learning, overall learning and retention. Between-group interaction analyses showed sequence-specific decreases in functional connectivity during overall learning in the right supplementary motor area (SMA). We found that connectivity changes in a key region of the motor network, the superior parietal cortex (SPC) were not a result of sequence-specific learning but were instead linked to motor execution. Our study confirms the sequence-specific role of SMA that has previously been identified in online task-based learning studies, and extends it to resting state network changes after sequence-specific MSL. |
format | Online Article Text |
id | pubmed-8930963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-89309632022-04-01 Motor sequences; separating the sequence from the motor. A longitudinal rsfMRI study Jäger, Anna-Thekla P. Huntenburg, Julia M. Tremblay, Stefanie A. Schneider, Uta Grahl, Sophia Huck, Julia Tardif, Christine L. Villringer, Arno Gauthier, Claudine J. Bazin, Pierre-Louis Steele, Christopher J. Brain Struct Funct Original Article In motor learning, sequence specificity, i.e. the learning of specific sequential associations, has predominantly been studied using task-based fMRI paradigms. However, offline changes in resting state functional connectivity after sequence-specific motor learning are less well understood. Previous research has established that plastic changes following motor learning can be divided into stages including fast learning, slow learning and retention. A description of how resting state functional connectivity after sequence-specific motor sequence learning (MSL) develops across these stages is missing. This study aimed to identify plastic alterations in whole-brain functional connectivity after learning a complex motor sequence by contrasting an active group who learned a complex sequence with a control group who performed a control task matched for motor execution. Resting state fMRI and behavioural performance were collected in both groups over the course of 5 consecutive training days and at follow-up after 12 days to encompass fast learning, slow learning, overall learning and retention. Between-group interaction analyses showed sequence-specific decreases in functional connectivity during overall learning in the right supplementary motor area (SMA). We found that connectivity changes in a key region of the motor network, the superior parietal cortex (SPC) were not a result of sequence-specific learning but were instead linked to motor execution. Our study confirms the sequence-specific role of SMA that has previously been identified in online task-based learning studies, and extends it to resting state network changes after sequence-specific MSL. Springer Berlin Heidelberg 2021-10-27 2022 /pmc/articles/PMC8930963/ /pubmed/34704176 http://dx.doi.org/10.1007/s00429-021-02412-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Jäger, Anna-Thekla P. Huntenburg, Julia M. Tremblay, Stefanie A. Schneider, Uta Grahl, Sophia Huck, Julia Tardif, Christine L. Villringer, Arno Gauthier, Claudine J. Bazin, Pierre-Louis Steele, Christopher J. Motor sequences; separating the sequence from the motor. A longitudinal rsfMRI study |
title | Motor sequences; separating the sequence from the motor. A longitudinal rsfMRI study |
title_full | Motor sequences; separating the sequence from the motor. A longitudinal rsfMRI study |
title_fullStr | Motor sequences; separating the sequence from the motor. A longitudinal rsfMRI study |
title_full_unstemmed | Motor sequences; separating the sequence from the motor. A longitudinal rsfMRI study |
title_short | Motor sequences; separating the sequence from the motor. A longitudinal rsfMRI study |
title_sort | motor sequences; separating the sequence from the motor. a longitudinal rsfmri study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930963/ https://www.ncbi.nlm.nih.gov/pubmed/34704176 http://dx.doi.org/10.1007/s00429-021-02412-7 |
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