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The NSAID glafenine rescues class 2 CFTR mutants via cyclooxygenase 2 inhibition of the arachidonic acid pathway
Most cases of cystic fibrosis (CF) are caused by class 2 mutations in the cystic fibrosis transmembrane regulator (CFTR). These proteins preserve some channel function but are retained in the endoplasmic reticulum (ER). Partial rescue of the most common CFTR class 2 mutant, F508del-CFTR, has been ac...
Autores principales: | Carlile, Graeme W., Yang, Qi, Matthes, Elizabeth, Liao, Jie, Birault, Véronique, Sneddon, Helen F., Poole, Darren L., Hall, Callum J., Hanrahan, John W., Thomas, David Y. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930988/ https://www.ncbi.nlm.nih.gov/pubmed/35302062 http://dx.doi.org/10.1038/s41598-022-08661-8 |
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