The NSAID glafenine rescues class 2 CFTR mutants via cyclooxygenase 2 inhibition of the arachidonic acid pathway

Most cases of cystic fibrosis (CF) are caused by class 2 mutations in the cystic fibrosis transmembrane regulator (CFTR). These proteins preserve some channel function but are retained in the endoplasmic reticulum (ER). Partial rescue of the most common CFTR class 2 mutant, F508del-CFTR, has been ac...

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Detalles Bibliográficos
Autores principales: Carlile, Graeme W., Yang, Qi, Matthes, Elizabeth, Liao, Jie, Birault, Véronique, Sneddon, Helen F., Poole, Darren L., Hall, Callum J., Hanrahan, John W., Thomas, David Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930988/
https://www.ncbi.nlm.nih.gov/pubmed/35302062
http://dx.doi.org/10.1038/s41598-022-08661-8

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