Multi-omic cross-sectional cohort study of pre-malignant Barrett’s esophagus reveals early structural variation and retrotransposon activity

Barrett’s esophagus is a pre-malignant lesion that can progress to esophageal adenocarcinoma. We perform a multi-omic analysis of pre-cancer samples from 146 patients with a range of outcomes, comprising 642 person years of follow-up. Whole genome sequencing reveals complex structural variants and L...

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Detalles Bibliográficos
Autores principales: Katz-Summercorn, A. C., Jammula, S., Frangou, A., Peneva, I., O’Donovan, M., Tripathi, M., Malhotra, S., di Pietro, M., Abbas, S., Devonshire, G., Januszewicz, W., Blasko, A., Nowicki-Osuch, K., MacRae, S., Northrop, A., Redmond, A. M., Wedge, D. C., Fitzgerald, R. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931005/
https://www.ncbi.nlm.nih.gov/pubmed/35301290
http://dx.doi.org/10.1038/s41467-022-28237-4

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