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Claudin1 decrease induced by 1,25-dihydroxy-vitamin D3 potentiates gefitinib resistance therapy through inhibiting AKT activation-mediated cancer stem-like properties in NSCLC cells

Claudins, the integral tight junction proteins that regulate paracellular permeability and cell polarity, are frequently dysregulated in cancer; however, their roles in regulating EGFR tyrosine kinase inhibitors (EGFR-TKIs) resistance in non-small cell lung cancer (NSCLC) are unknown. To this end, w...

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Detalles Bibliográficos
Autores principales:	Jia, Zhirong, Wang, Kaiwei, Duan, Yalei, Hu, Kaiyong, Zhang, Yameng, Wang, Meisa, Xiao, Kang, Liu, Shuo, Pan, Zhenzhen, Ding, Xuansheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931006/ https://www.ncbi.nlm.nih.gov/pubmed/35301287 http://dx.doi.org/10.1038/s41420-022-00918-5

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