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Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease

Platelet-derived growth factor-BB (PDGF-BB):PDGF receptor-β (PDGFRβ) signalling in brain pericytes is critical to the development, maintenance and function of a healthy blood-brain barrier (BBB). Furthermore, BBB impairment and pericyte loss in Alzheimer’s disease (AD) is well documented. We found t...

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Detalles Bibliográficos
Autores principales:	Smyth, Leon C. D., Highet, Blake, Jansson, Deidre, Wu, Jane, Rustenhoven, Justin, Aalderink, Miranda, Tan, Adelie, Li, Susan, Johnson, Rebecca, Coppieters, Natacha, Handley, Renee, Narayan, Pritika, Singh-Bains, Malvindar K., Schweder, Patrick, Turner, Clinton, Mee, Edward W., Heppner, Peter, Correia, Jason, Park, Thomas I.-H., Curtis, Maurice A., Faull, Richard L. M., Dragunow, Mike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931009/ https://www.ncbi.nlm.nih.gov/pubmed/35301433 http://dx.doi.org/10.1038/s42003-022-03180-8

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