Dioscin Alleviates Cardiac Dysfunction in Acute Myocardial Infarction via Rescuing Mitochondrial Malfunction

Myocardial infarction is one of the most severe heart diseases, leading to sudden death. Currently, angiography and stenting are widely performed in clinics, yet more effective treatment is still needed. Herein, we presented that dioscin, a natural product, showed protective effect on infarcted hear...

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Autores principales: Shen, Tianyu, Lyu, Dayin, Zhang, Mengping, Shang, Hui, Lu, Qiulun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931042/
https://www.ncbi.nlm.nih.gov/pubmed/35310994
http://dx.doi.org/10.3389/fcvm.2022.783426
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author Shen, Tianyu
Lyu, Dayin
Zhang, Mengping
Shang, Hui
Lu, Qiulun
author_facet Shen, Tianyu
Lyu, Dayin
Zhang, Mengping
Shang, Hui
Lu, Qiulun
author_sort Shen, Tianyu
collection PubMed
description Myocardial infarction is one of the most severe heart diseases, leading to sudden death. Currently, angiography and stenting are widely performed in clinics, yet more effective treatment is still needed. Herein, we presented that dioscin, a natural product, showed protective effect on infarcted hearts via mitochondrial maintenance. Upon dioscin treatment, cardiac dysfunction was alleviated, and remodeling is prevented. Mechanistically, disocin maintains mitochondria function through the maintenance of Kreb's cycle, and suppresion of ROS accumulation. In this way, by targeting mitochondrial dysfunction, dioscin is a potential drug for infarcted hearts.
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spelling pubmed-89310422022-03-19 Dioscin Alleviates Cardiac Dysfunction in Acute Myocardial Infarction via Rescuing Mitochondrial Malfunction Shen, Tianyu Lyu, Dayin Zhang, Mengping Shang, Hui Lu, Qiulun Front Cardiovasc Med Cardiovascular Medicine Myocardial infarction is one of the most severe heart diseases, leading to sudden death. Currently, angiography and stenting are widely performed in clinics, yet more effective treatment is still needed. Herein, we presented that dioscin, a natural product, showed protective effect on infarcted hearts via mitochondrial maintenance. Upon dioscin treatment, cardiac dysfunction was alleviated, and remodeling is prevented. Mechanistically, disocin maintains mitochondria function through the maintenance of Kreb's cycle, and suppresion of ROS accumulation. In this way, by targeting mitochondrial dysfunction, dioscin is a potential drug for infarcted hearts. Frontiers Media S.A. 2022-03-04 /pmc/articles/PMC8931042/ /pubmed/35310994 http://dx.doi.org/10.3389/fcvm.2022.783426 Text en Copyright © 2022 Shen, Lyu, Zhang, Shang and Lu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Shen, Tianyu
Lyu, Dayin
Zhang, Mengping
Shang, Hui
Lu, Qiulun
Dioscin Alleviates Cardiac Dysfunction in Acute Myocardial Infarction via Rescuing Mitochondrial Malfunction
title Dioscin Alleviates Cardiac Dysfunction in Acute Myocardial Infarction via Rescuing Mitochondrial Malfunction
title_full Dioscin Alleviates Cardiac Dysfunction in Acute Myocardial Infarction via Rescuing Mitochondrial Malfunction
title_fullStr Dioscin Alleviates Cardiac Dysfunction in Acute Myocardial Infarction via Rescuing Mitochondrial Malfunction
title_full_unstemmed Dioscin Alleviates Cardiac Dysfunction in Acute Myocardial Infarction via Rescuing Mitochondrial Malfunction
title_short Dioscin Alleviates Cardiac Dysfunction in Acute Myocardial Infarction via Rescuing Mitochondrial Malfunction
title_sort dioscin alleviates cardiac dysfunction in acute myocardial infarction via rescuing mitochondrial malfunction
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931042/
https://www.ncbi.nlm.nih.gov/pubmed/35310994
http://dx.doi.org/10.3389/fcvm.2022.783426
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