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KPT330 improves Cas9 precision genome- and base-editing by selectively regulating mRNA nuclear export

CRISPR-based genome engineering tools are associated with off-target effects that constitutively active Cas9 protein may instigate. Previous studies have revealed the feasibility of modulating Cas9-based genome- and base-editing tools using protein or small-molecule CRISPR inhibitors. Here we screen...

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Detalles Bibliográficos
Autores principales:	Cui, Yan-ru, Wang, Shao-jie, Ma, Tiancheng, Yu, Peihong, Chen, Jun, Guo, Taijie, Meng, Genyi, Jiang, Biao, Dong, Jiajia, Liu, Jia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931069/ https://www.ncbi.nlm.nih.gov/pubmed/35301428 http://dx.doi.org/10.1038/s42003-022-03188-0

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