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Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication

Human rhinovirus (HRV), like coronavirus (HCoV), are positive-strand RNA viruses that cause both upper and lower respiratory tract illness, with their replication facilitated by concentrating RNA-synthesizing machinery in intracellular compartments made of modified host membranes, referred to as rep...

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Autores principales: Triantafilou, Martha, Ramanjulu, Joshi, Booty, Lee M., Jimenez-Duran, Gisela, Keles, Hakan, Saunders, Ken, Nevins, Neysa, Koppe, Emma, Modis, Louise K., Pesiridis, G. Scott, Bertin, John, Triantafilou, Kathy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931115/
https://www.ncbi.nlm.nih.gov/pubmed/35301296
http://dx.doi.org/10.1038/s41467-022-28745-3
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author Triantafilou, Martha
Ramanjulu, Joshi
Booty, Lee M.
Jimenez-Duran, Gisela
Keles, Hakan
Saunders, Ken
Nevins, Neysa
Koppe, Emma
Modis, Louise K.
Pesiridis, G. Scott
Bertin, John
Triantafilou, Kathy
author_facet Triantafilou, Martha
Ramanjulu, Joshi
Booty, Lee M.
Jimenez-Duran, Gisela
Keles, Hakan
Saunders, Ken
Nevins, Neysa
Koppe, Emma
Modis, Louise K.
Pesiridis, G. Scott
Bertin, John
Triantafilou, Kathy
author_sort Triantafilou, Martha
collection PubMed
description Human rhinovirus (HRV), like coronavirus (HCoV), are positive-strand RNA viruses that cause both upper and lower respiratory tract illness, with their replication facilitated by concentrating RNA-synthesizing machinery in intracellular compartments made of modified host membranes, referred to as replication organelles (ROs). Here we report a non-canonical, essential function for stimulator of interferon genes (STING) during HRV infections. While the canonical function of STING is to detect cytosolic DNA and activate inflammatory responses, HRV infection triggers the release of STIM1-bound STING in the ER by lowering Ca(2+), thereby allowing STING to interact with phosphatidylinositol 4-phosphate (PI4P) and traffic to ROs to facilitates viral replication and transmission via autophagy. Our results thus hint a critical function of STING in HRV viral replication and transmission, with possible implications for other RO-mediated RNA viruses.
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spelling pubmed-89311152022-04-01 Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication Triantafilou, Martha Ramanjulu, Joshi Booty, Lee M. Jimenez-Duran, Gisela Keles, Hakan Saunders, Ken Nevins, Neysa Koppe, Emma Modis, Louise K. Pesiridis, G. Scott Bertin, John Triantafilou, Kathy Nat Commun Article Human rhinovirus (HRV), like coronavirus (HCoV), are positive-strand RNA viruses that cause both upper and lower respiratory tract illness, with their replication facilitated by concentrating RNA-synthesizing machinery in intracellular compartments made of modified host membranes, referred to as replication organelles (ROs). Here we report a non-canonical, essential function for stimulator of interferon genes (STING) during HRV infections. While the canonical function of STING is to detect cytosolic DNA and activate inflammatory responses, HRV infection triggers the release of STIM1-bound STING in the ER by lowering Ca(2+), thereby allowing STING to interact with phosphatidylinositol 4-phosphate (PI4P) and traffic to ROs to facilitates viral replication and transmission via autophagy. Our results thus hint a critical function of STING in HRV viral replication and transmission, with possible implications for other RO-mediated RNA viruses. Nature Publishing Group UK 2022-03-17 /pmc/articles/PMC8931115/ /pubmed/35301296 http://dx.doi.org/10.1038/s41467-022-28745-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Triantafilou, Martha
Ramanjulu, Joshi
Booty, Lee M.
Jimenez-Duran, Gisela
Keles, Hakan
Saunders, Ken
Nevins, Neysa
Koppe, Emma
Modis, Louise K.
Pesiridis, G. Scott
Bertin, John
Triantafilou, Kathy
Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
title Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
title_full Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
title_fullStr Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
title_full_unstemmed Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
title_short Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
title_sort human rhinovirus promotes sting trafficking to replication organelles to promote viral replication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931115/
https://www.ncbi.nlm.nih.gov/pubmed/35301296
http://dx.doi.org/10.1038/s41467-022-28745-3
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