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Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka

The objective of this review is to evaluate the anti-dementia activities of saffron and its combination with Kampo medicine. The Kampo formula Kamiuntanto composed of 13 crude drugs is well known for its anti-dementia activity. A significant increase in choline acetyltransferase activity and mRNA le...

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Autores principales: Kuchta, Kenny, Aritake, Kosuke, Urade, Yoshihiro, Tung, Nguyen Huu, Yuan, Chun-Su, Sasaki, Yui, Shimizu, Koichi, Shoyama, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931200/
https://www.ncbi.nlm.nih.gov/pubmed/35310894
http://dx.doi.org/10.3389/fphar.2021.779821
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author Kuchta, Kenny
Aritake, Kosuke
Urade, Yoshihiro
Tung, Nguyen Huu
Yuan, Chun-Su
Sasaki, Yui
Shimizu, Koichi
Shoyama, Yukihiro
author_facet Kuchta, Kenny
Aritake, Kosuke
Urade, Yoshihiro
Tung, Nguyen Huu
Yuan, Chun-Su
Sasaki, Yui
Shimizu, Koichi
Shoyama, Yukihiro
author_sort Kuchta, Kenny
collection PubMed
description The objective of this review is to evaluate the anti-dementia activities of saffron and its combination with Kampo medicine. The Kampo formula Kamiuntanto composed of 13 crude drugs is well known for its anti-dementia activity. A significant increase in choline acetyltransferase activity and mRNA levels were observed. Polygala radix was identified as the most essential component drug in Kamiuntanto, probably due to the saponins, tenuifolin, and sinapinic acid. Ginseng was also identified as an essential Kamiuntanto component in terms of its synergistic functions with Polygala radix. Saffron, which was recommended in the Bencao Gangmu for memory and dementia, and is used as an anti-spasmodic, anti-catarrhal, and sedative herbal drug. Saffron and its major constituent, crocin were shown to enhance learning-memory, non-rapid eye movement (rem) sleep, and inhibit depression and neuronal cell death due to strong anti-oxidant and anti-inflammation activities. In addition based on the epidemiological studies such as the treatment of sleeping disorders and the clinical trials of saffron for Alzheimer patients, we demonstrated the indirect and direct anti-dementia activities of crocin and saffron.
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spelling pubmed-89312002022-03-19 Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka Kuchta, Kenny Aritake, Kosuke Urade, Yoshihiro Tung, Nguyen Huu Yuan, Chun-Su Sasaki, Yui Shimizu, Koichi Shoyama, Yukihiro Front Pharmacol Pharmacology The objective of this review is to evaluate the anti-dementia activities of saffron and its combination with Kampo medicine. The Kampo formula Kamiuntanto composed of 13 crude drugs is well known for its anti-dementia activity. A significant increase in choline acetyltransferase activity and mRNA levels were observed. Polygala radix was identified as the most essential component drug in Kamiuntanto, probably due to the saponins, tenuifolin, and sinapinic acid. Ginseng was also identified as an essential Kamiuntanto component in terms of its synergistic functions with Polygala radix. Saffron, which was recommended in the Bencao Gangmu for memory and dementia, and is used as an anti-spasmodic, anti-catarrhal, and sedative herbal drug. Saffron and its major constituent, crocin were shown to enhance learning-memory, non-rapid eye movement (rem) sleep, and inhibit depression and neuronal cell death due to strong anti-oxidant and anti-inflammation activities. In addition based on the epidemiological studies such as the treatment of sleeping disorders and the clinical trials of saffron for Alzheimer patients, we demonstrated the indirect and direct anti-dementia activities of crocin and saffron. Frontiers Media S.A. 2022-03-04 /pmc/articles/PMC8931200/ /pubmed/35310894 http://dx.doi.org/10.3389/fphar.2021.779821 Text en Copyright © 2022 Kuchta, Aritake, Urade, Tung, Yuan, Sasaki, Shimizu and Shoyama. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Kuchta, Kenny
Aritake, Kosuke
Urade, Yoshihiro
Tung, Nguyen Huu
Yuan, Chun-Su
Sasaki, Yui
Shimizu, Koichi
Shoyama, Yukihiro
Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka
title Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka
title_full Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka
title_fullStr Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka
title_full_unstemmed Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka
title_short Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka
title_sort preventing dementia using saffron, the kampo medicine, kamiuntanto, and their combination, kamiuntantokabankoka
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931200/
https://www.ncbi.nlm.nih.gov/pubmed/35310894
http://dx.doi.org/10.3389/fphar.2021.779821
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