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Poly-dipeptides produced from C9orf72 hexanucleotide repeats cause selective motor neuron hyperexcitability in ALS
Expansion of the GGGGCC hexanucleotide repeat in the chromosome 9 open reading frame 72 (C9orf72) gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS). As in other forms of ALS, selective hyperexcitability of the motor cortex has been implicated as a cause of the motor neuron...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931230/ https://www.ncbi.nlm.nih.gov/pubmed/35259014 http://dx.doi.org/10.1073/pnas.2113813119 |