A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged variant of sonic hedgehog

Sonic Hedgehog (Shh) is a key signaling molecule that plays important roles in various developmental processes in mammals. Although the signal transduction pathway activated by Shh is well understood, the regulation of its secretion remains unclear. Newly synthesized Shh is imported into the endopla...

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Detalles Bibliográficos
Autores principales: Tang, Xiao, Chen, Rong, Mesias, Vince St Dollente, Wang, Tingxuan, Wang, Ying, Poljak, Kristina, Fan, Xinyu, Miao, Hanchi, Hu, Junjie, Zhang, Liang, Huang, Jinqing, Yao, Shuhuai, Miller, Elizabeth A., Guo, Yusong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931250/
https://www.ncbi.nlm.nih.gov/pubmed/35271396
http://dx.doi.org/10.1073/pnas.2113991119

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