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Resolving the subtle details of human DNA alkyltransferase lesion search and repair mechanism by single-molecule studies

The O(6)-alkylguanine DNA alkyltransferase (AGT) is an important DNA repair protein. AGT repairs highly mutagenic and cytotoxic alkylguanine lesions that result from metabolic products but are also deliberately introduced during chemotherapy, making a better understanding of the working mechanism of...

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Detalles Bibliográficos
Autores principales:	Kono, Sarah, van den Berg, Aafke, Simonetta, Marco, Mukhortava, Ann, Garman, Elspeth F., Tessmer, Ingrid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931253/ https://www.ncbi.nlm.nih.gov/pubmed/35259021 http://dx.doi.org/10.1073/pnas.2116218119

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