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Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation

OBJECTIVE: To discuss the histological features, pathological types, and prognosis of gastric adenocarcinoma with mucinous differentiation. METHODS: Specimens of 189 cases of gastric adenocarcinoma with mucinous differentiation were collected for detailed histomorphology, immunohistochemistry, fluor...

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Autores principales: Meng, Nian-Long, Wang, Yang-kun, Wang, Hai-Li, Zhou, Jun-Ling, Wang, Su-nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931263/
https://www.ncbi.nlm.nih.gov/pubmed/35308509
http://dx.doi.org/10.3389/fmed.2022.829702
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author Meng, Nian-Long
Wang, Yang-kun
Wang, Hai-Li
Zhou, Jun-Ling
Wang, Su-nan
author_facet Meng, Nian-Long
Wang, Yang-kun
Wang, Hai-Li
Zhou, Jun-Ling
Wang, Su-nan
author_sort Meng, Nian-Long
collection PubMed
description OBJECTIVE: To discuss the histological features, pathological types, and prognosis of gastric adenocarcinoma with mucinous differentiation. METHODS: Specimens of 189 cases of gastric adenocarcinoma with mucinous differentiation were collected for detailed histomorphology, immunohistochemistry, fluorescence in situ hybridization, and follow-up. RESULTS: In accordance with the morphological and histological structural features of the cancer cells as well as the area ratio of the mucus, gastric adenocarcinoma with mucinous differentiation was divided into four types, namely pure mucinous carcinoma, intraductal papillary mucinous carcinoma, signet ring cell type mucinous carcinoma, and mixed cell type mucinous carcinoma. Based on the macroscopic types according to Bormann's classification, pure mucinous carcinoma was mostly Type I, intraductal papillary mucinous carcinoma was mostly Type II, signet ring cell type mucinous carcinoma was mostly Type IV, and mixed cell type mucinous carcinoma was mostly Type III. The 5-year survival rate was 69.2, 64.2, 0, and 31.5%, respectively. There was a statistical difference in the lymph node metastasis rate and survival rate of the four carcinoma types. The invasion features of pure mucinous carcinoma entailed penetrating corrosively in a push-in form, without blood vessel or lymphatic metastasis and with few lymphocytes and lymphatic nodules in the marginal area. Thus, there was little lymph node metastasis and invasion of nerves. The HER2 protein expression rate was 40.2% (76/189), the HER2 gene amplification detected by FISH technology was 16.9% (32/189). CONCLUSION: The independent histological type, four subtypes, and histopathological classification of gastric mucinous adenocarcinoma are important for the prognosis evaluation and precise treatment of this disease.
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spelling pubmed-89312632022-03-19 Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation Meng, Nian-Long Wang, Yang-kun Wang, Hai-Li Zhou, Jun-Ling Wang, Su-nan Front Med (Lausanne) Medicine OBJECTIVE: To discuss the histological features, pathological types, and prognosis of gastric adenocarcinoma with mucinous differentiation. METHODS: Specimens of 189 cases of gastric adenocarcinoma with mucinous differentiation were collected for detailed histomorphology, immunohistochemistry, fluorescence in situ hybridization, and follow-up. RESULTS: In accordance with the morphological and histological structural features of the cancer cells as well as the area ratio of the mucus, gastric adenocarcinoma with mucinous differentiation was divided into four types, namely pure mucinous carcinoma, intraductal papillary mucinous carcinoma, signet ring cell type mucinous carcinoma, and mixed cell type mucinous carcinoma. Based on the macroscopic types according to Bormann's classification, pure mucinous carcinoma was mostly Type I, intraductal papillary mucinous carcinoma was mostly Type II, signet ring cell type mucinous carcinoma was mostly Type IV, and mixed cell type mucinous carcinoma was mostly Type III. The 5-year survival rate was 69.2, 64.2, 0, and 31.5%, respectively. There was a statistical difference in the lymph node metastasis rate and survival rate of the four carcinoma types. The invasion features of pure mucinous carcinoma entailed penetrating corrosively in a push-in form, without blood vessel or lymphatic metastasis and with few lymphocytes and lymphatic nodules in the marginal area. Thus, there was little lymph node metastasis and invasion of nerves. The HER2 protein expression rate was 40.2% (76/189), the HER2 gene amplification detected by FISH technology was 16.9% (32/189). CONCLUSION: The independent histological type, four subtypes, and histopathological classification of gastric mucinous adenocarcinoma are important for the prognosis evaluation and precise treatment of this disease. Frontiers Media S.A. 2022-03-04 /pmc/articles/PMC8931263/ /pubmed/35308509 http://dx.doi.org/10.3389/fmed.2022.829702 Text en Copyright © 2022 Meng, Wang, Wang, Zhou and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Meng, Nian-Long
Wang, Yang-kun
Wang, Hai-Li
Zhou, Jun-Ling
Wang, Su-nan
Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation
title Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation
title_full Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation
title_fullStr Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation
title_full_unstemmed Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation
title_short Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation
title_sort research on the histological features and pathological types of gastric adenocarcinoma with mucinous differentiation
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931263/
https://www.ncbi.nlm.nih.gov/pubmed/35308509
http://dx.doi.org/10.3389/fmed.2022.829702
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