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A Spontaneous H2-Aa Point Mutation Impairs MHC II Synthesis and CD4(+) T-Cell Development in Mice

Major histocompatibility complex class II (MHC II) is an essential immune regulatory molecule that plays an important role in antigen presentation and T-cell development. Abnormal MHC II expression can lead to immunodeficiency, clinically termed as type II bare lymphocyte syndrome (BLS), which usual...

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Detalles Bibliográficos
Autores principales:	Zhao, Yun, Xiong, Juan, Chen, Hai-Xia, Zhang, Min, Zhou, Li-Na, Wu, Yin-Fang, Li, Wei-Jie, Fei, Xia, Li, Fei, Zhu, Chen, Li, Wen, Ying, Song-Min, Wang, Lie, Chen, Zhi-Hua, Shen, Hua-Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931304/ https://www.ncbi.nlm.nih.gov/pubmed/35309308 http://dx.doi.org/10.3389/fimmu.2022.810824

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