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Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease

Dipeptidyl-peptidase IV (DPP4), originally identified as an aminopeptidase in 1960s, is an ubiquitously expressed protease presented as either a membrane-bound or soluble form. DPP4 cleaves dipeptide off from the N-terminal of its substrates, altering the bioactivity of its substrates. Subsequent st...

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Autores principales: Huang, Jie, Liu, Xinxin, Wei, Yingying, Li, Xinlu, Gao, Shupei, Dong, Lingli, Rao, Xiaoquan, Zhong, Jixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931313/
https://www.ncbi.nlm.nih.gov/pubmed/35309368
http://dx.doi.org/10.3389/fimmu.2022.830863
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author Huang, Jie
Liu, Xinxin
Wei, Yingying
Li, Xinlu
Gao, Shupei
Dong, Lingli
Rao, Xiaoquan
Zhong, Jixin
author_facet Huang, Jie
Liu, Xinxin
Wei, Yingying
Li, Xinlu
Gao, Shupei
Dong, Lingli
Rao, Xiaoquan
Zhong, Jixin
author_sort Huang, Jie
collection PubMed
description Dipeptidyl-peptidase IV (DPP4), originally identified as an aminopeptidase in 1960s, is an ubiquitously expressed protease presented as either a membrane-bound or soluble form. DPP4 cleaves dipeptide off from the N-terminal of its substrates, altering the bioactivity of its substrates. Subsequent studies reveal that DPP4 is also involved in various cellular processes by directly binding to a number of ligands, including adenosine deaminase, CD45, fibronectin, plasminogen, and caveolin-1. In recent years, many novel functions of DPP4, such as promoting fibrosis and mediating virus entry, have been discovered. Due to its implication in fibrotic response and immunoregulation, increasing studies are focusing on the potential role of DPP4 in inflammatory disorders. As a moonlighting protein, DPP4 possesses multiple functions in different types of cells, including both enzymatic and non-enzymatic functions. However, most of the review articles on the role of DPP4 in autoimmune disease were focused on the association between DPP4 enzymatic inhibitors and the risk of autoimmune disease. An updated comprehensive summary of DPP4’s immunoregulatory actions including both enzymatic dependent and independent functions is needed. In this article, we will review the recent advances of DPP4 in immune regulation and autoimmune rheumatic disease.
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spelling pubmed-89313132022-03-19 Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease Huang, Jie Liu, Xinxin Wei, Yingying Li, Xinlu Gao, Shupei Dong, Lingli Rao, Xiaoquan Zhong, Jixin Front Immunol Immunology Dipeptidyl-peptidase IV (DPP4), originally identified as an aminopeptidase in 1960s, is an ubiquitously expressed protease presented as either a membrane-bound or soluble form. DPP4 cleaves dipeptide off from the N-terminal of its substrates, altering the bioactivity of its substrates. Subsequent studies reveal that DPP4 is also involved in various cellular processes by directly binding to a number of ligands, including adenosine deaminase, CD45, fibronectin, plasminogen, and caveolin-1. In recent years, many novel functions of DPP4, such as promoting fibrosis and mediating virus entry, have been discovered. Due to its implication in fibrotic response and immunoregulation, increasing studies are focusing on the potential role of DPP4 in inflammatory disorders. As a moonlighting protein, DPP4 possesses multiple functions in different types of cells, including both enzymatic and non-enzymatic functions. However, most of the review articles on the role of DPP4 in autoimmune disease were focused on the association between DPP4 enzymatic inhibitors and the risk of autoimmune disease. An updated comprehensive summary of DPP4’s immunoregulatory actions including both enzymatic dependent and independent functions is needed. In this article, we will review the recent advances of DPP4 in immune regulation and autoimmune rheumatic disease. Frontiers Media S.A. 2022-03-04 /pmc/articles/PMC8931313/ /pubmed/35309368 http://dx.doi.org/10.3389/fimmu.2022.830863 Text en Copyright © 2022 Huang, Liu, Wei, Li, Gao, Dong, Rao and Zhong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Huang, Jie
Liu, Xinxin
Wei, Yingying
Li, Xinlu
Gao, Shupei
Dong, Lingli
Rao, Xiaoquan
Zhong, Jixin
Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease
title Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease
title_full Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease
title_fullStr Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease
title_full_unstemmed Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease
title_short Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease
title_sort emerging role of dipeptidyl peptidase-4 in autoimmune disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931313/
https://www.ncbi.nlm.nih.gov/pubmed/35309368
http://dx.doi.org/10.3389/fimmu.2022.830863
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