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Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation

The nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing 3 (NLRP3) responds to a vast variety of stimuli, and activated NLRP3 forms an inflammasome, which in turn is associated with conditions such as atherosclerosis, Alzheimer’s disease, and diabetes. A multilayered...

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Detalles Bibliográficos
Autores principales:	Ohto, Umeharu, Kamitsukasa, Yukie, Ishida, Hanako, Zhang, Zhikuan, Murakami, Karin, Hirama, Chie, Maekawa, Sakiko, Shimizu, Toshiyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931350/ https://www.ncbi.nlm.nih.gov/pubmed/35254907 http://dx.doi.org/10.1073/pnas.2121353119

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