Deep learning guided optimization of human antibody against SARS-CoV-2 variants with broad neutralization

The ability of viruses to mutate and evade the human immune system and neutralizing antibodies remains an obstacle to antiviral and vaccine development. Many neutralizing antibodies, including some approved for emergency use authorization (EUA), reduced or lost activity against severe acute respirat...

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Detalles Bibliográficos
Autores principales: Shan, Sisi, Luo, Shitong, Yang, Ziqing, Hong, Junxian, Su, Yufeng, Ding, Fan, Fu, Lili, Li, Chenyu, Chen, Peng, Ma, Jianzhu, Shi, Xuanling, Zhang, Qi, Berger, Bonnie, Zhang, Linqi, Peng, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931377/
https://www.ncbi.nlm.nih.gov/pubmed/35238654
http://dx.doi.org/10.1073/pnas.2122954119

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