Case Report: Detection of Transferrin in a Dog Suspected of Having Cerebrospinal Fluid Rhinorrhea

A 12-year-old Yorkshire terrier was referred for epileptic seizures and nasal discharge. The fluid was clear and serous. Cerebrospinal fluid (CSF) rhinorrhea was suspected, based on clinical signs and MRI findings. In humans, analysis of nasal secretions to determine the concentration of glucose and...

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Autores principales: Kinoshita, Kosuke, Nishida, Hidetaka, Kanegi, Ryoji, Nakamoto, Yuya, Tanaka, Toshiyuki, Shimamura, Shunsuke, Kusumoto, Kazuhito, Akiyoshi, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931393/
https://www.ncbi.nlm.nih.gov/pubmed/35310418
http://dx.doi.org/10.3389/fvets.2022.845809
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author Kinoshita, Kosuke
Nishida, Hidetaka
Kanegi, Ryoji
Nakamoto, Yuya
Tanaka, Toshiyuki
Shimamura, Shunsuke
Kusumoto, Kazuhito
Akiyoshi, Hideo
author_facet Kinoshita, Kosuke
Nishida, Hidetaka
Kanegi, Ryoji
Nakamoto, Yuya
Tanaka, Toshiyuki
Shimamura, Shunsuke
Kusumoto, Kazuhito
Akiyoshi, Hideo
author_sort Kinoshita, Kosuke
collection PubMed
description A 12-year-old Yorkshire terrier was referred for epileptic seizures and nasal discharge. The fluid was clear and serous. Cerebrospinal fluid (CSF) rhinorrhea was suspected, based on clinical signs and MRI findings. In humans, analysis of nasal secretions to determine the concentration of glucose and brain-type transferrin has been widely used clinically in order to confirm the presence of CSF rhinorrhea. The glucose concentration in the nasal discharge was 74 mg/dL. Serum-type and brain-type isoforms of transferrin were detectable in the nasal sample. The concentration of glucose and brain-type transferrin could be useful for diagnosing CSF rhinorrhea.
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spelling pubmed-89313932022-03-19 Case Report: Detection of Transferrin in a Dog Suspected of Having Cerebrospinal Fluid Rhinorrhea Kinoshita, Kosuke Nishida, Hidetaka Kanegi, Ryoji Nakamoto, Yuya Tanaka, Toshiyuki Shimamura, Shunsuke Kusumoto, Kazuhito Akiyoshi, Hideo Front Vet Sci Veterinary Science A 12-year-old Yorkshire terrier was referred for epileptic seizures and nasal discharge. The fluid was clear and serous. Cerebrospinal fluid (CSF) rhinorrhea was suspected, based on clinical signs and MRI findings. In humans, analysis of nasal secretions to determine the concentration of glucose and brain-type transferrin has been widely used clinically in order to confirm the presence of CSF rhinorrhea. The glucose concentration in the nasal discharge was 74 mg/dL. Serum-type and brain-type isoforms of transferrin were detectable in the nasal sample. The concentration of glucose and brain-type transferrin could be useful for diagnosing CSF rhinorrhea. Frontiers Media S.A. 2022-03-04 /pmc/articles/PMC8931393/ /pubmed/35310418 http://dx.doi.org/10.3389/fvets.2022.845809 Text en Copyright © 2022 Kinoshita, Nishida, Kanegi, Nakamoto, Tanaka, Shimamura, Kusumoto and Akiyoshi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Kinoshita, Kosuke
Nishida, Hidetaka
Kanegi, Ryoji
Nakamoto, Yuya
Tanaka, Toshiyuki
Shimamura, Shunsuke
Kusumoto, Kazuhito
Akiyoshi, Hideo
Case Report: Detection of Transferrin in a Dog Suspected of Having Cerebrospinal Fluid Rhinorrhea
title Case Report: Detection of Transferrin in a Dog Suspected of Having Cerebrospinal Fluid Rhinorrhea
title_full Case Report: Detection of Transferrin in a Dog Suspected of Having Cerebrospinal Fluid Rhinorrhea
title_fullStr Case Report: Detection of Transferrin in a Dog Suspected of Having Cerebrospinal Fluid Rhinorrhea
title_full_unstemmed Case Report: Detection of Transferrin in a Dog Suspected of Having Cerebrospinal Fluid Rhinorrhea
title_short Case Report: Detection of Transferrin in a Dog Suspected of Having Cerebrospinal Fluid Rhinorrhea
title_sort case report: detection of transferrin in a dog suspected of having cerebrospinal fluid rhinorrhea
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931393/
https://www.ncbi.nlm.nih.gov/pubmed/35310418
http://dx.doi.org/10.3389/fvets.2022.845809
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