Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction

OBJECTIVE: Parental environmental exposures can strongly influence descendant risks for adult disease. How paternal obesity changes the sperm chromatin leading to the acquisition of metabolic disease in offspring remains controversial and ill-defined. The objective of this study was to assess (1) wh...

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Detalles Bibliográficos
Autores principales: Pepin, Anne-Sophie, Lafleur, Christine, Lambrot, Romain, Dumeaux, Vanessa, Kimmins, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931445/
https://www.ncbi.nlm.nih.gov/pubmed/35183795
http://dx.doi.org/10.1016/j.molmet.2022.101463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931445/
https://www.ncbi.nlm.nih.gov/pubmed/35183795
http://dx.doi.org/10.1016/j.molmet.2022.101463

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