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Effect of Hypoxic Blood Infusion on Pulmonary Physiology
The ability to store red blood cells (RBCs) and other components for extended periods of time has expanded the availability and use of transfusion as a life-saving therapy. However, conventional RBC storage has a limited window of effective preservation and is accompanied by the progressive accumula...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931507/ https://www.ncbi.nlm.nih.gov/pubmed/35309066 http://dx.doi.org/10.3389/fphys.2022.842510 |
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author | Pittman, Roland N. Yoshida, Tatsuro Omert, Laurel A. |
author_facet | Pittman, Roland N. Yoshida, Tatsuro Omert, Laurel A. |
author_sort | Pittman, Roland N. |
collection | PubMed |
description | The ability to store red blood cells (RBCs) and other components for extended periods of time has expanded the availability and use of transfusion as a life-saving therapy. However, conventional RBC storage has a limited window of effective preservation and is accompanied by the progressive accumulation of a series of biochemical and morphological modifications, collectively referred to as “storage lesions.” These lesions have been associated with negative clinical outcomes (i.e., postoperative complications as well as reduced short-term and long-term survival) in patients transfused with conventionally stored blood with older and deteriorated transfused red cells. Hence, there is an increased unmet need for improved RBC storage. Hypoxic storage of blood entails the removal of large amounts of oxygen to low levels prior to refrigeration and maintenance of hypoxic levels through the entirety of storage. As opposed to conventionally stored blood, hypoxic storage can lead to a reduction of oxidative damage to slow storage lesion development and create a storage condition expected to result in enhanced efficacy of stored RBCs without an effect on oxygen exchange in the lung. Hypoxic blood transfusions appear to offer minimal safety concerns, even in patients with hypoxemia. This review describes the physiology of hypoxically stored blood, how it differs from conventionally stored blood, and its use in potential clinical application, such as massively transfused and critically ill patients with oxygenation/ventilation impairments. |
format | Online Article Text |
id | pubmed-8931507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89315072022-03-19 Effect of Hypoxic Blood Infusion on Pulmonary Physiology Pittman, Roland N. Yoshida, Tatsuro Omert, Laurel A. Front Physiol Physiology The ability to store red blood cells (RBCs) and other components for extended periods of time has expanded the availability and use of transfusion as a life-saving therapy. However, conventional RBC storage has a limited window of effective preservation and is accompanied by the progressive accumulation of a series of biochemical and morphological modifications, collectively referred to as “storage lesions.” These lesions have been associated with negative clinical outcomes (i.e., postoperative complications as well as reduced short-term and long-term survival) in patients transfused with conventionally stored blood with older and deteriorated transfused red cells. Hence, there is an increased unmet need for improved RBC storage. Hypoxic storage of blood entails the removal of large amounts of oxygen to low levels prior to refrigeration and maintenance of hypoxic levels through the entirety of storage. As opposed to conventionally stored blood, hypoxic storage can lead to a reduction of oxidative damage to slow storage lesion development and create a storage condition expected to result in enhanced efficacy of stored RBCs without an effect on oxygen exchange in the lung. Hypoxic blood transfusions appear to offer minimal safety concerns, even in patients with hypoxemia. This review describes the physiology of hypoxically stored blood, how it differs from conventionally stored blood, and its use in potential clinical application, such as massively transfused and critically ill patients with oxygenation/ventilation impairments. Frontiers Media S.A. 2022-03-04 /pmc/articles/PMC8931507/ /pubmed/35309066 http://dx.doi.org/10.3389/fphys.2022.842510 Text en Copyright © 2022 Pittman, Yoshida and Omert. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Pittman, Roland N. Yoshida, Tatsuro Omert, Laurel A. Effect of Hypoxic Blood Infusion on Pulmonary Physiology |
title | Effect of Hypoxic Blood Infusion on Pulmonary Physiology |
title_full | Effect of Hypoxic Blood Infusion on Pulmonary Physiology |
title_fullStr | Effect of Hypoxic Blood Infusion on Pulmonary Physiology |
title_full_unstemmed | Effect of Hypoxic Blood Infusion on Pulmonary Physiology |
title_short | Effect of Hypoxic Blood Infusion on Pulmonary Physiology |
title_sort | effect of hypoxic blood infusion on pulmonary physiology |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931507/ https://www.ncbi.nlm.nih.gov/pubmed/35309066 http://dx.doi.org/10.3389/fphys.2022.842510 |
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