Material properties of phase-separated TFEB condensates regulate the autophagy-lysosome pathway

Very little is known about how the material properties of protein condensates assembled via liquid–liquid phase separation (LLPS) are maintained and affect physiological functions. Here we show that liquid-like condensates of the transcription factor TFEB exhibit low fusion propensity in vitro and i...

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Detalles Bibliográficos
Autores principales: Wang, Zheng, Chen, Di, Guan, Dongshi, Liang, Xiaobo, Xue, Jianfeng, Zhao, Hongyu, Song, Guangtao, Lou, Jizhong, He, Yan, Zhang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931539/
https://www.ncbi.nlm.nih.gov/pubmed/35293953
http://dx.doi.org/10.1083/jcb.202112024

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