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Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF-7 cells
Breast cancer is one of the most challenging diseases to treat in humans worldwide. There are several alternatives in treating this life-threatening disease; however, chemoresistance is probably the biggest obstacle to the treatment of breast cancer. It may be essential to develop a therapeutic cand...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931636/ https://www.ncbi.nlm.nih.gov/pubmed/35340876 http://dx.doi.org/10.3892/etm.2022.11235 |
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author | Kang, Seong Hee Bak, Dong-Ho Yeoup Chung, Byung Bai, Hyoung-Woo |
author_facet | Kang, Seong Hee Bak, Dong-Ho Yeoup Chung, Byung Bai, Hyoung-Woo |
author_sort | Kang, Seong Hee |
collection | PubMed |
description | Breast cancer is one of the most challenging diseases to treat in humans worldwide. There are several alternatives in treating this life-threatening disease; however, chemoresistance is probably the biggest obstacle to the treatment of breast cancer. It may be essential to develop a therapeutic candidate material with less reversible effects and high treatment efficiency to solve this problem. The present study applied an ionizing radiation approach employing nomifensine (NF) to transform its chemical characteristics and investigated its potential to kill human breast cancer cells (MCF-7). Irradiated (IR-) NF was analyzed using high-performance liquid chromatography. The findings showed that NF inhibited the proliferation of breast cancer cells and increased the rate of apoptosis. In addition, IR-NF induced the accumulation of cytosolic reactive oxygen species and enhanced mitochondrial aggregation. Additionally, mitogen-activated protein kinases (extracellular signal-regulated kinase 1/2, p38 and c-Jun NH 2-terminal kinase) were involved in damage signaling induced by IR-NF and IR-NF suppressed β-catenin nuclear translocation. It is suggested that irradiation can be an effective method to maximize the efficacy of existing drugs and that IR-NF has the potential to be a drug candidate for treating patients with breast cancer. |
format | Online Article Text |
id | pubmed-8931636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-89316362022-03-25 Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF-7 cells Kang, Seong Hee Bak, Dong-Ho Yeoup Chung, Byung Bai, Hyoung-Woo Exp Ther Med Articles Breast cancer is one of the most challenging diseases to treat in humans worldwide. There are several alternatives in treating this life-threatening disease; however, chemoresistance is probably the biggest obstacle to the treatment of breast cancer. It may be essential to develop a therapeutic candidate material with less reversible effects and high treatment efficiency to solve this problem. The present study applied an ionizing radiation approach employing nomifensine (NF) to transform its chemical characteristics and investigated its potential to kill human breast cancer cells (MCF-7). Irradiated (IR-) NF was analyzed using high-performance liquid chromatography. The findings showed that NF inhibited the proliferation of breast cancer cells and increased the rate of apoptosis. In addition, IR-NF induced the accumulation of cytosolic reactive oxygen species and enhanced mitochondrial aggregation. Additionally, mitogen-activated protein kinases (extracellular signal-regulated kinase 1/2, p38 and c-Jun NH 2-terminal kinase) were involved in damage signaling induced by IR-NF and IR-NF suppressed β-catenin nuclear translocation. It is suggested that irradiation can be an effective method to maximize the efficacy of existing drugs and that IR-NF has the potential to be a drug candidate for treating patients with breast cancer. D.A. Spandidos 2022-04 2022-02-23 /pmc/articles/PMC8931636/ /pubmed/35340876 http://dx.doi.org/10.3892/etm.2022.11235 Text en Copyright: © Kang et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Kang, Seong Hee Bak, Dong-Ho Yeoup Chung, Byung Bai, Hyoung-Woo Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF-7 cells |
title | Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF-7 cells |
title_full | Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF-7 cells |
title_fullStr | Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF-7 cells |
title_full_unstemmed | Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF-7 cells |
title_short | Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF-7 cells |
title_sort | transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in mcf-7 cells |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931636/ https://www.ncbi.nlm.nih.gov/pubmed/35340876 http://dx.doi.org/10.3892/etm.2022.11235 |
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